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SYT14P1 synaptotagmin 14 pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 401135, updated on 23-Nov-2023

Summary

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Official Symbol
SYT14P1provided by HGNC
Official Full Name
synaptotagmin 14 pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:33429
See related
MIM:610892; AllianceGenome:HGNC:33429
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYT14L; SYTDEP; CHR415SYT
Summary
Involved in positive regulation of CREB transcription factor activity; positive regulation of ERK1 and ERK2 cascade; and positive regulation of dendrite extension. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
4q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (68060610..68063297, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (71503796..71506479, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (68926328..68929015, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene POLR2M pseudogene 1 Neighboring gene MT-ND2 pseudogene 41 Neighboring gene transmembrane serine protease 11F Neighboring gene uncharacterized LOC550113 Neighboring gene solute carrier family 47 member 2 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:68979095-68979596 Neighboring gene TMPRSS11B N-terminal like (pseudogene) Neighboring gene ferritin light chain pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene. Herrero-Turrión MJ, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16376304
  2. Genomic analysis of synaptotagmin genes. Craxton M. Genomics, 2001 Sep. PMID 11543631
  3. Synaptotagmin gene content of the sequenced genomes. Craxton M. BMC Genomics, 2004 Jul 6. PMID 15238157, Free PMC Article
  4. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SYT14L, especially its C2 domain, may play an important role in the regulation of dendricity in melanocytes.
    Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.
  2. Genomic analyses suggest that human sytdep could derive from a retrotranslocation of a synaptotagmin XIV transcript into chromosome 4.
    Title: Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • chr415 synaptotagmin
  • synaptotagmin XIV pseudogene 1
  • synaptotagmin XIV-derived
  • synaptotagmin XIV-like

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY954513, BC132697, CR740599

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    68060610..68063297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    71503796..71506479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014372.3: Suppressed sequence

    Description
    NM_001014372.3: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58G82.2 GenPept UniProtKB/Swiss-Prot:Q58G82

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.