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PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ]

Gene ID: 400961, updated on 5-Mar-2024

Summary

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Official Symbol
PAIP2Bprovided by HGNC
Official Full Name
poly(A) binding protein interacting protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:29200
See related
Ensembl:ENSG00000124374 MIM:611018; AllianceGenome:HGNC:29200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues See more
Orthologs
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Genomic context

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See PAIP2B in Genome Data Viewer
Location:
2p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (71182738..71227103, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (71193792..71238156, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71409868..71454233, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71345289-71345789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71356582-71357440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16015 Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16016 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:71384714-71384875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:71388687-71389348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411093-71411594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411595-71412094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71453663-71454163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71477764-71478264 Neighboring gene uncharacterized LOC105374797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71558505-71559192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71559193-71559878 Neighboring gene Sharpr-MPRA regulatory region 7735 Neighboring gene zinc finger protein 638 Neighboring gene RNA, U6 small nuclear 105, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Tang H, et al. Int J Cancer, 2017 Aug 15. PMID 28470677, Free PMC Article
  2. Regulation of poly(A)-binding protein through PABP-interacting proteins. Derry MC, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381337
  3. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. Berlanga JJ, et al. RNA, 2006 Aug. PMID 16804161, Free PMC Article
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
  5. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Youn JY, et al. Mol Cell, 2018 Feb 1. PMID 29395067

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
polyadenylate-binding protein-interacting protein 2B
Names
PABP-interacting protein 2B
PAIP-2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020459.1 → NP_065192.1  polyadenylate-binding protein-interacting protein 2B

    See identical proteins and their annotated locations for NP_065192.1

    Status: VALIDATED

    Source sequence(s)
    AB032981, AC007881, DA247526, DA346299
    Consensus CDS
    CCDS46322.1
    UniProtKB/Swiss-Prot
    Q9ULR5
    Related
    ENSP00000244221.8, ENST00000244221.9
    Conserved Domains (1) summary
    pfam07145
    Location:107 → 120
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    71182738..71227103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264311.5 → XP_005264368.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_005264368.1

    UniProtKB/Swiss-Prot
    Q9ULR5
    Conserved Domains (1) summary
    pfam07145
    Location:107 → 120
    PAM2; Ataxin-2 C-terminal region

  2. XM_005264310.5 → XP_005264367.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_005264367.1

    UniProtKB/Swiss-Prot
    Q9ULR5
    Conserved Domains (1) summary
    pfam07145
    Location:107 → 120
    PAM2; Ataxin-2 C-terminal region

  3. XM_011532842.4 → XP_011531144.1  polyadenylate-binding protein-interacting protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011531144.1

    Conserved Domains (1) summary
    pfam07145
    Location:127 → 141
    PAM2; Ataxin-2 C-terminal region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    71193792..71238156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342026.1 → XP_054198001.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q9ULR5

  2. XM_054342025.1 → XP_054198000.1  polyadenylate-binding protein-interacting protein 2B isoform X1

  3. XM_054342027.1 → XP_054198002.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q9ULR5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULR5.2 GenPept UniProtKB/Swiss-Prot:Q9ULR5

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