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MIRLET7BHG MIRLET7B host gene [ Homo sapiens (human) ]

Gene ID: 400931, updated on 16-Mar-2024

Summary

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Official Symbol
MIRLET7BHGprovided by HGNC
Official Full Name
MIRLET7B host geneprovided by HGNC
Primary source
HGNC:HGNC:37189
See related
Ensembl:ENSG00000197182 MIM:618216; AllianceGenome:HGNC:37189
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
linc-Ppara
Expression
Biased expression in skin (RPKM 5.0), placenta (RPKM 2.2) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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See MIRLET7BHG in Genome Data Viewer
Location:
22q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46085997..46113928)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (46570566..46598616)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46481877..46509808)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(III) chain-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19231 Neighboring gene PRR34 antisense RNA 1 Neighboring gene PRR34 long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46467816-46468370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46468371-46468923 Neighboring gene long intergenic non-protein coding RNA 2939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46480369-46480940 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:46481213-46482412 Neighboring gene uncharacterized LOC112268288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46483852-46484461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46500537-46501051 Neighboring gene microRNA 3619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46506657-46507190 Neighboring gene microRNA let-7a-3 Neighboring gene microRNA let-7b Neighboring gene microRNA 4763 Neighboring gene uncharacterized LOC124905137 Neighboring gene uncharacterized LOC124905138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46533901-46534402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19232 Neighboring gene uncharacterized LOC105373074 Neighboring gene peroxisome proliferator activated receptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis. Bakin RE, et al. J Biol Chem, 2004 Dec 3. PMID 15364908
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Sauvageau M, et al. Elife, 2013 Dec 31. PMID 24381249, Free PMC Article
  3. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • MIRLET7B host gene (non-protein coding)

Clone Names

  • FLJ27365

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027033.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK023424, AK130875, FP325332

  2. NR_110479.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AK023424, AK130875, FP325332
    Related
    ENST00000360737.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    46085997..46113928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    46570566..46598616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207477.1: Suppressed sequence

    Description
    NM_207477.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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