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Mkp3 Mitogen-activated protein kinase phosphatase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40081, updated on 11-Apr-2024

Summary

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Official Symbol
Mkp3provided by FlyBase
Official Full Name
Mitogen-activated protein kinase phosphatase 3provided by FlyBase
Primary source
FLYBASE:FBgn0036844
Locus tag
Dmel_CG14080
See related
AllianceGenome:FB:FBgn0036844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14080; CG14081; Dmel\CG14080; DMKP-3; dMKP3; Dmkp3; DMKP3; mkp-3; mkp3; MKP3
Summary
Enables MAP kinase tyrosine phosphatase activity. Involved in several processes, including imaginal disc-derived wing vein specification; negative regulation of signal transduction; and open tracheal system development. Located in cytosol. Is expressed in several structures, including ectoderm anlage; germ layer; muscle system; presumptive embryonic/larval system; and stage 5 embryo. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to several human genes including DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Mkp3 in Genome Data Viewer
Location:
75F6-75F6; 3-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19066155..19086426, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19059255..19079526, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 316 member A1 Neighboring gene Sideroflexin 2 Neighboring gene long non-coding RNA:CR45386 Neighboring gene Misexpression suppressor of ras 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of Drosophila MKP-3 by Drosophila ERK. Kim SE, et al. Ann N Y Acad Sci, 2003 Dec. PMID 15033693
  2. Drosophila extracellular signal-regulated kinase involves the insulin-mediated proliferation of Schneider cells. Kwon HB, et al. J Biol Chem, 2002 Apr 26. PMID 11834735
  3. New Insights from Drosophila into the Regulation of EGFR Signaling. Harden N. Methods Mol Biol, 2017. PMID 28791632
  4. An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila. Mogila V, et al. Dev Cell, 2006 Oct. PMID 17011495, Free PMC Article
  5. Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase. Kim SH, et al. Biochem J, 2002 Jan 1. PMID 11742539, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that Tay bridge antagonizes EGFR signalling in the Drosophila melanogaster wing disc and other tissues, and that the protein interacts with both Erk and Mkp3
    Title: Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing.
  2. Study suggests that Mkp3 constitutes a conserved negative feedback loop on the activity of the Ras/ERK signaling pathway.
    Title: Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3.
  3. MKP-3 is critically involved in cell differentiation, proliferation, and gene expression by suppressing the Ras/ERK pathway, specifically binding to ERK via the N-terminal ERK-binding domain of MKP-3.
    Title: MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development.
  4. Drosophila ERK specifically regulates DMKP-3 in terms of its enzyme activity and protein stability esssential for regulation.
    Title: Regulation of Drosophila MKP-3 by Drosophila ERK.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mitogen-activated protein kinase phosphatase 3
Names
CG14080-PA
CG14080-PB
CG14080-PC
CG14080-PD
ERK-inhibitory phosphatase
MAP kinase phosphatase 3
MAPK phosphatase 3
MAPK phosphatase-3
MKP-3-like
MKP-like
Mkp3-PA
Mkp3-PB
Mkp3-PC
Mkp3-PD
drosophila MKP-3
NP_001262031.1
NP_001262032.1
NP_649087.1
NP_730385.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19066155..19086426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275103.1 → NP_001262032.1  Mitogen-activated protein kinase phosphatase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86P14, Q95SV1, Q9VVW4, Q9VVW5
    UniProtKB/TrEMBL
    M9PFW0
    Conserved Domains (2) summary
    cd01446
    Location:8 → 148
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14566
    Location:215 → 352
    DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase

  2. NM_001275102.1 → NP_001262031.1  Mitogen-activated protein kinase phosphatase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262031.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG13
    Conserved Domains (3) summary
    COG2453
    Location:242 → 359
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:215 → 353
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:8 → 148
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

  3. NM_168785.1 → NP_730385.1  Mitogen-activated protein kinase phosphatase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVW5
    Related
    FBpp0074803, FBtr0075036
    Conserved Domains (2) summary
    COG2453
    Location:72 → 189
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:45 → 183
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  4. NM_140830.2 → NP_649087.1  Mitogen-activated protein kinase phosphatase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649087.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86P14, Q95SV1, Q9VVW4, Q9VVW5
    UniProtKB/TrEMBL
    M9PFW0
    Related
    FBpp0074802
    Conserved Domains (2) summary
    cd01446
    Location:8 → 148
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14566
    Location:215 → 352
    DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFW0 M9PFW0
M9PG13 M9PG13
Q9VVW5.2 Q9VVW5

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