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LINC00668 long intergenic non-protein coding RNA 668 [ Homo sapiens (human) ]

Gene ID: 400643, updated on 25-Dec-2023

Summary

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Official Symbol
LINC00668provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 668provided by HGNC
Primary source
HGNC:HGNC:44328
See related
Ensembl:ENSG00000265933 AllianceGenome:HGNC:44328
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 11.7), colon (RPKM 6.5) and 4 other tissues See more
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Genomic context

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Location:
18p11.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (6925474..6929869, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (7086009..7090408, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (6925473..6929868, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985176 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:6605546-6606358 Neighboring gene RNA, 7SL, cytoplasmic 282, pseudogene Neighboring gene ARHGAP28 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6729485-6730448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740450-6740950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740951-6741451 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6751961-6752536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6752537-6753112 Neighboring gene Rho GTPase activating protein 28 Neighboring gene NANOG hESC enhancer GRCh37_chr18:6782830-6783412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:6951323-6951880 Neighboring gene uncharacterized LOC101927188 Neighboring gene RNA, U6 small nuclear 916, pseudogene Neighboring gene SCML2 pseudogene 1 Neighboring gene laminin subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and 
Promotes Tumor Cell Migration and Invasion]. Yuan B, et al. Zhongguo Fei Ai Za Zhi, 2022 Apr 20. PMID 35477186, Free PMC Article
  2. LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation. Liu Z, et al. Neurochem Res, 2020 Jul. PMID 32279214
  3. LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis. Xuan W, et al. Biosci Rep, 2020 May 29. PMID 32249890, Free PMC Article
  4. Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma. Wang X, et al. Int J Oncol, 2019 Oct. PMID 31432149, Free PMC Article
  5. Expression profile analysis identifies the long non-coding RNA landscape and the potential carcinogenic functions of LINC00668 in laryngeal squamous cell carcinoma. Zhao L, et al. Gene, 2019 Mar 1. PMID 30415008

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis.
    Title: LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis.
  2. [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and Promotes Tumor Cell Migration and Invasion].
    Title: [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and 
Promotes Tumor Cell Migration and Invasion].
  3. LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation.
    Title: LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation.
  4. LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis.
    Title: LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis.
  5. Study identified that lncRNA LINC00668 is differentially expressed and upregulated in hepatocellular carcinoma (HCC) tissue. It functions as an oncogene and its high expression leads to poor prognosis for HCC.
    Title: Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma.
  6. STAT3-induced LINC00668 contributed to non-small cell lung cancer progression through upregulating KLF7 expression by sponging miR-193a.
    Title: STAT3-induced long noncoding RNA LINC00668 promotes migration and invasion of non-small cell lung cancer via the miR-193a/KLF7 axis.
  7. lncRNA LINC00668 acted as an oncogenic role in CRC cells by sponging miR-188-5p and upregulating USP47
    Title: LINC00668 promotes tumorigenesis and progression through sponging miR-188-5p and regulating USP47 in colorectal cancer.
  8. High LINC00668 expression is associated with laryngeal squamous cell carcinoma.
    Title: Expression profile analysis identifies the long non-coding RNA landscape and the potential carcinogenic functions of LINC00668 in laryngeal squamous cell carcinoma.
  9. High LINC00668 expression is associated with gastric cancer.
    Title: E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Clone Names

  • FLJ38028

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_034100.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP005210
    Related
    ENST00000581571.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    6925474..6929869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    7086009..7090408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001103383.1: Suppressed sequence

    Description
    NM_001103383.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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