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TRIM49D1 tripartite motif containing 49D1 [ Homo sapiens (human) ]

Gene ID: 399939, updated on 23-Nov-2023

Summary

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Official Symbol
TRIM49D1provided by HGNC
Official Full Name
tripartite motif containing 49D1provided by HGNC
Primary source
HGNC:HGNC:43973
See related
Ensembl:ENSG00000223417 AllianceGenome:HGNC:43973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIM49D; TRIM49D2; TRIM49DP; TRIM49D1P; TRIM49D2P
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See TRIM49D1 in Genome Data Viewer
Location:
11q14.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89911409..89922245, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89831356..89840458, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89644577..89655413, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene MT-ND1 pseudogene 35 Neighboring gene tripartite motif containing 49D2 Neighboring gene cell adhesion associated, oncogene regulated pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 49D
Names
tripartite motif containing 49D, pseudogene
tripartite motif containing 49D1, pseudogene
tripartite motif-containing protein 49-like protein
tripartite motif-containing protein 49D1
tripartite motif-containing protein 49D2 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206627.2 → NP_001193556.1  tripartite motif-containing protein 49D

    See identical proteins and their annotated locations for NP_001193556.1

    Status: VALIDATED

    Source sequence(s)
    AP004607, AP005814
    Consensus CDS
    CCDS60930.1
    UniProtKB/Swiss-Prot
    C9J1S8, I1YAP9
    UniProtKB/TrEMBL
    A0A087WVN7
    Related
    ENSP00000474850.1, ENST00000530311.6
    Conserved Domains (3) summary
    cd16603
    Location:12 → 57
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cd19783
    Location:87 → 139
    Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285 → 448
    SPRY; SPRY domain

  2. NM_001384911.1 → NP_001371840.1  tripartite motif-containing protein 49D

    Status: VALIDATED

    Source sequence(s)
    AP004607, AP005814
    Consensus CDS
    CCDS60930.1
    UniProtKB/Swiss-Prot
    C9J1S8, I1YAP9
    UniProtKB/TrEMBL
    A0A087WVN7
    Related
    ENSP00000474678.1, ENST00000420869.3
    Conserved Domains (3) summary
    cd16603
    Location:12 → 57
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cd19783
    Location:87 → 139
    Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285 → 448
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    89911409..89922245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    89831356..89840458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9J1S8.1 GenPept UniProtKB/Swiss-Prot:C9J1S8

Gene LinkOut

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