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Lratd2 LRAT domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 399603, updated on 5-Mar-2024

Summary

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Official Symbol
Lratd2provided by MGI
Official Full Name
LRAT domain containing 1provided by MGI
Primary source
MGI:MGI:3026924
See related
Ensembl:ENSMUSG00000072568 AllianceGenome:MGI:3026924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam84b; D330050I23Rik
Summary
Predicted to be located in cytoplasm and plasma membrane. Is expressed in alimentary system; brain; metanephros; and vibrissa. Orthologous to human LRATD2 (LRAT domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 18.5), ovary adult (RPKM 9.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Lratd2 in Genome Data Viewer
Location:
15 D1; 15 25.7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (60690845..60697954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (60818996..60826105, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23835 Neighboring gene alpha-1-B glycoprotein pseudogene Neighboring gene RIKEN cDNA 9930014A18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11590 Neighboring gene VISTA enhancer mm642 Neighboring gene predicted gene, 53894 Neighboring gene alpha-1-B glycoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. Homer-Bouthiette C, et al. BMC Cancer, 2018 Dec 10. PMID 30526553, Free PMC Article
  2. A genetic analysis of neural progenitor differentiation. Geschwind DH, et al. Neuron, 2001 Feb. PMID 11239426
  3. Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Uslu VV, et al. Nat Genet, 2014 Jul. PMID 24859337
  4. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose Myc as a candidate susceptibility gene, regulated by the gene desert locus, and a potential role for Fam84b in modifying breast cancer development.
    Title: Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein LRATD2
Names
family with sequence similarity 84, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162926.1 → NP_001156398.1  protein LRATD2

    Status: VALIDATED

    Source sequence(s)
    AK139928, AK162412, BY426787, CN663980
    Consensus CDS
    CCDS49613.1
    UniProtKB/TrEMBL
    D3YXJ5
    Related
    ENSMUSP00000098200.4, ENSMUST00000100635.5
    Conserved Domains (1) summary
    cl21534
    Location:130 → 212
    NLPC_P60; NlpC/P60 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    60690845..60697954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_384024.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207269.1: Suppressed sequence

    Description
    NM_207269.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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