U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 399510, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Map4k5provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5provided by MGI
Primary source
MGI:MGI:1925503
See related
Ensembl:ENSMUSG00000034761 AllianceGenome:MGI:1925503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KHS; GCKR; MAPKKKK5; 4432415E19Rik
Summary
Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Is expressed in metanephros and testis. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Map4k5 in Genome Data Viewer
Location:
12 C2; 12 28.94 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69850531..69939937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69803757..69893163, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene distal membrane arm assembly component 2 like Neighboring gene VISTA enhancer mm122 Neighboring gene cyclin dependent kinase like 1 Neighboring gene microRNA 681 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene STARR-seq mESC enhancer starr_32378 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 4931403G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E8487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70968432-70968671 Neighboring gene STARR-seq mESC enhancer starr_32379 Neighboring gene atlastin GTPase 1 Neighboring gene STARR-seq mESC enhancer starr_32381 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene predicted gene, 52003 Neighboring gene salvador family WW domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Shi CS, et al. Mol Cell Biol, 2006 Sep. PMID 16914735, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Germinal center kinase-related enzyme (GCKR) facilitates both canonical and noncanonical Wnt signaling in B lymphocytes.
    Title: The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5
Names
MAPK/ERK kinase kinase kinase 5
MEK kinase kinase 5
MEKKK 5
NP_958927.2
XP_006516117.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201519.2 → NP_958927.2  mitogen-activated protein kinase kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_958927.2

    Status: VALIDATED

    Source sequence(s)
    AK019468, AK032123, AK053775, AK084891, BC048173
    UniProtKB/Swiss-Prot
    Q6PEQ2, Q8BPM2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73
    UniProtKB/TrEMBL
    E9PX30
    Conserved Domains (3) summary
    smart00036
    Location:512 → 827
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69850531..69939937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516054.4 → XP_006516117.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    See identical proteins and their annotated locations for XP_006516117.1

    UniProtKB/TrEMBL
    E9PX30
    Related
    ENSMUSP00000106199.2, ENSMUST00000110570.8
    Conserved Domains (2) summary
    smart00036
    Location:512 → 826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPM2.2 GenPept UniProtKB/Swiss-Prot:Q8BPM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous