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Agpat4 1-Acylglycerol-3-phosphate O-acyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39819, updated on 4-Apr-2024

Summary

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Official Symbol
Agpat4provided by FlyBase
Official Full Name
1-Acylglycerol-3-phosphate O-acyltransferase 4provided by FlyBase
Primary source
FLYBASE:FBgn0036622
Locus tag
Dmel_CG4753
See related
AllianceGenome:FB:FBgn0036622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AGPAT; AGPAT4; CG4753; DmAGPAT3-5; Dmel\CG4753
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be active in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
72E4-72E4; 3-44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16378974..16381570, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16372074..16374670, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 3 Neighboring gene RING-associated factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes. Schlame M, et al. Chem Phys Lipids, 2012 Jul. PMID 22465155
  2. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
  3. Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Bailey AP, et al. Cell, 2015 Oct 8. PMID 26451484, Free PMC Article
  4. Diverse roles of phosphatidate phosphatases in insect development and metabolism. Lehmann M. Insect Biochem Mol Biol, 2021 Jun. PMID 32931938, Free PMC Article
  5. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-Acylglycerol-3-phosphate O-acyltransferase 4
Names
Agpat4-PA
Agpat4-PB
Agpat4-PC
CG4753-PA
CG4753-PB
CG4753-PC
NP_001261942.1
NP_648887.1
NP_730158.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16378974..16381570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140630.3 → NP_648887.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV49
    Related
    FBpp0075179
    Conserved Domains (3) summary
    cd07990
    Location:58 → 255
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 366
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:243 → 320
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001275013.1 → NP_001261942.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV49
    Conserved Domains (3) summary
    cd07990
    Location:58 → 255
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 366
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:243 → 320
    Acyltransf_C; Acyltransferase C-terminus

  3. NM_168660.2 → NP_730158.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730158.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV49
    Related
    FBpp0075180
    Conserved Domains (3) summary
    cd07990
    Location:58 → 255
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 366
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:243 → 320
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VV49 Q9VV49

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