U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LGALS7 galectin 7 [ Homo sapiens (human) ]

Gene ID: 3963, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LGALS7provided by HGNC
Official Full Name
galectin 7provided by HGNC
Primary source
HGNC:HGNC:6568
See related
Ensembl:ENSG00000205076 MIM:600615; AllianceGenome:HGNC:6568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL7; LGALS7A
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 300.6) See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38770968..38773517, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41575026..41577575, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39261608..39264157, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene uncharacterized LOC107985291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39193145-39193645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39195255-39196024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39198444-39199230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39208396-39209241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39209276-39209996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39217269-39218152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14592 Neighboring gene uncharacterized LOC124904711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14593 Neighboring gene calpain 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39283071-39283770 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:39287723-39288637 Neighboring gene galectin 7B Neighboring gene RNA, U6 small nuclear 140, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions. Liang Y, et al. Int J Mol Sci, 2022 Oct 14. PMID 36293173, Free PMC Article
  2. Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7. Pham NTH, et al. J Biol Chem, 2021 Nov. PMID 34673030, Free PMC Article
  3. Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity. Ludwig AK, et al. Histochem Cell Biol, 2021 Sep. PMID 34152508, Free PMC Article
  4. Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7. Chapman JR, et al. Amyloid, 2021 Mar. PMID 32867548, Free PMC Article
  5. Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice. Menkhorst E, et al. Hypertension, 2020 Oct. PMID 32862708

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
    Title: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
  2. Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
    Title: Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
  3. Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
    Title: Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
  4. CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
    Title: CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
  5. Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
    Title: Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
  6. Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
    Title: Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
  7. Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
    Title: Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
  8. Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
    Title: Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
  9. Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression.
    Title: Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression.
  10. Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
    Title: Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

General protein information

Go to the top of the page Help
Preferred Names
galectin-7
Names
lectin, galactoside-binding, soluble, 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002307.4 → NP_002298.1  galectin-7

    See identical proteins and their annotated locations for NP_002298.1

    Status: REVIEWED

    Source sequence(s)
    BP225960
    Consensus CDS
    CCDS33012.1
    UniProtKB/Swiss-Prot
    P47929, Q6IB87
    Related
    ENSP00000367891.3, ENST00000378626.5
    Conserved Domains (1) summary
    smart00908
    Location:11 → 133
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38770968..38773517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p14 PATCHES

    Range
    180608..183157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41575026..41577575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321017.1 → XP_054176992.1  galectin-7 isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous