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Sf3a2 Splicing factor 3a subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39456, updated on 11-Apr-2024

Summary

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Official Symbol
Sf3a2provided by FlyBase
Official Full Name
Splicing factor 3a subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0036314
Locus tag
Dmel_CG10754
See related
AllianceGenome:FB:FBgn0036314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10754; CG2807; Dmel\CG10754; SF3A2
Summary
Predicted to enable RNA binding activity. Involved in positive regulation of gene expression. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in anterior endoderm; head mesoderm; organism; posterior endoderm; and trunk mesoderm. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
69E4-69E4; 3-39 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12813028..12814019, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12806128..12807119, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46251 Neighboring gene Sin3A-associated protein 130 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nebulosa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Edwards AC, et al. Genetics, 2009 Jul. PMID 19414563, Free PMC Article
  2. Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation. Pellacani C, et al. Elife, 2018 Nov 26. PMID 30475206, Free PMC Article
  3. Identification of novel elements of the Drosophila blisterome sheds light on potential pathological mechanisms of several human diseases. Bilousov O, et al. PLoS One, 2014. PMID 24968325, Free PMC Article
  4. Conserved functions of RNA-binding proteins in muscle. Nikonova E, et al. Int J Biochem Cell Biol, 2019 May. PMID 30818081
  5. A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in a Drosophila melanogaster Model Population. Duun Rohde P, et al. Int J Genomics, 2016. PMID 27274984, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
splicing factor 3a subunit 2
Names
CG10754-PA
Sf3a2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12813028..12814019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140346.2 → NP_648603.1  splicing factor 3a subunit 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648603.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VU15
    Related
    FBpp0075676
    Conserved Domains (3) summary
    smart00451
    Location:52 → 85
    ZnF_U1; U1-like zinc finger
    COG5246
    Location:1 → 214
    PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
    pfam16835
    Location:129 → 207
    SF3A2; Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VU15 Q9VU15

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