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Serpinb3d serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D [ Mus musculus (house mouse) ]

Gene ID: 394252, updated on 8-Feb-2024

Summary

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Official Symbol
Serpinb3dprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3Dprovided by MGI
Primary source
MGI:MGI:2683295
See related
Ensembl:ENSMUSG00000058017 AllianceGenome:MGI:2683295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Serpinb3l1
Summary
Predicted to enable endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytoplasmic vesicle; extracellular exosome; and nucleus. Predicted to be active in extracellular space. Orthologous to human SERPINB3 (serpin family B member 3) and SERPINB4 (serpin family B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
1 E2.1; 1 50.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107005893..107011210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107078163..107083480, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A Neighboring gene STARR-seq mESC enhancer starr_01865 Neighboring gene STARR-seq mESC enhancer starr_01866 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice. Lunardi F, et al. Lab Invest, 2011 Jun. PMID 21403642
  2. The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases. Askew DJ, et al. Genomics, 2004 Jul. PMID 15203214
  3. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Askew DJ, et al. Genomics, 2004 Jul. PMID 15203215
  4. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
  5. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.
    Title: Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serpin B3
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3D
serine proteinase inhibitor B3-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201376.1 → NP_958764.1  serpin B3

    See identical proteins and their annotated locations for NP_958764.1

    Status: PROVISIONAL

    Source sequence(s)
    AY367776
    Consensus CDS
    CCDS15215.1
    UniProtKB/TrEMBL
    Q6IE30, Q6UKZ0
    Related
    ENSMUSP00000023861.4, ENSMUST00000023861.5
    Conserved Domains (1) summary
    cl00137
    Location:7 → 387
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    107005893..107011210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321551.1 → XP_017177040.1  serpin B3 isoform X2

    UniProtKB/TrEMBL
    Q6IE30
    Conserved Domains (1) summary
    cl38926
    Location:1 → 365
    serpin; SERine Proteinase INhibitors (serpin) family

  2. XM_017321541.1 → XP_017177030.1  serpin B3 isoform X1

    UniProtKB/TrEMBL
    Q6IE30
    Conserved Domains (1) summary
    cl38926
    Location:1 → 386
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version

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