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VSIG8 V-set and immunoglobulin domain containing 8 [ Homo sapiens (human) ]

Gene ID: 391123, updated on 5-Mar-2024

Summary

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Official Symbol
VSIG8provided by HGNC
Official Full Name
V-set and immunoglobulin domain containing 8provided by HGNC
Primary source
HGNC:HGNC:32063
See related
Ensembl:ENSG00000243284 AllianceGenome:HGNC:32063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 5.5), kidney (RPKM 1.8) and 4 other tissues See more
Orthologs
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Genomic context

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See VSIG8 in Genome Data Viewer
Location:
1q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159854316..159862657, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158991321..158999665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159824106..159832447, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159815652-159816152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159816153-159816653 Neighboring gene small nucleolar RNA SNORD64 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1455 Neighboring gene uncharacterized LOC107985216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159830948-159831862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159831863-159832775 Neighboring gene Sharpr-MPRA regulatory region 5062 Neighboring gene cilia and flagella associated protein 45 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:159859176-159860375 Neighboring gene uncharacterized LOC124904434 Neighboring gene microRNA 4259

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, et al. Mol Cell Biol, 2015 Jan. PMID 25332235, Free PMC Article
  2. Charting the molecular network of the drug target Bcr-Abl. Brehme M, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19380743, Free PMC Article
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods NT, et al. Sci Signal, 2012 Sep 18. PMID 22990118, Free PMC Article
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
  5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CFAP45

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-set and immunoglobulin domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013661.1 → NP_001013683.1  V-set and immunoglobulin domain-containing protein 8 precursor

    See identical proteins and their annotated locations for NP_001013683.1

    Status: VALIDATED

    Source sequence(s)
    AL590560
    Consensus CDS
    CCDS30913.1
    UniProtKB/Swiss-Prot
    P0DPA2
    Related
    ENSP00000357080.1, ENST00000368100.1
    Conserved Domains (2) summary
    smart00410
    Location:160 → 256
    IG_like; Immunoglobulin like
    pfam07686
    Location:35 → 142
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159854316..159862657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158991321..158999665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DPA2.1 GenPept UniProtKB/Swiss-Prot:P0DPA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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