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ZNF793 zinc finger protein 793 [ Homo sapiens (human) ]

Gene ID: 390927, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF793provided by HGNC
Official Full Name
zinc finger protein 793provided by HGNC
Primary source
HGNC:HGNC:33115
See related
Ensembl:ENSG00000188227 AllianceGenome:HGNC:33115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Implicated in Barrett's esophagus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.6), brain (RPKM 1.5) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37506428..37543333)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40307906..40345149)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37997841..38034235)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1 Neighboring gene zinc finger protein 540 Neighboring gene MT-ND4 pseudogene 41 Neighboring gene zinc finger protein 571 Neighboring gene MT-ND5 pseudogene 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus. Yu M, et al. Cancer Epidemiol Biomarkers Prev, 2015 Dec. PMID 26545406, Free PMC Article
  2. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 793

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013659.3 → NP_001013681.2  zinc finger protein 793

    See identical proteins and their annotated locations for NP_001013681.2

    Status: VALIDATED

    Source sequence(s)
    AC022148, AK131417, BE219465, BU683546, BX537524, DB180171
    Consensus CDS
    CCDS46062.1
    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9
    Related
    ENSP00000487183.2, ENST00000627814.3
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:225 → 385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229 → 249
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37506428..37543333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438816.1 → XP_047294772.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  2. XM_047438820.1 → XP_047294776.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  3. XM_047438815.1 → XP_047294771.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  4. XM_006723213.4 → XP_006723276.1  zinc finger protein 793 isoform X1

    See identical proteins and their annotated locations for XP_006723276.1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:225 → 385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229 → 249
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047438822.1 → XP_047294778.1  zinc finger protein 793 isoform X2

  6. XM_047438814.1 → XP_047294770.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  7. XM_047438819.1 → XP_047294775.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  8. XM_047438817.1 → XP_047294773.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  9. XM_047438813.1 → XP_047294769.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  10. XM_047438818.1 → XP_047294774.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9
    Related
    ENSP00000468605.1, ENST00000587143.5

  11. XM_047438821.1 → XP_047294777.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9
    Related
    ENSP00000396402.1, ENST00000445217.5

  12. XM_047438823.1 → XP_047294779.1  zinc finger protein 793 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40307906..40345149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320997.1 → XP_054176972.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  2. XM_054320992.1 → XP_054176967.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  3. XM_054320998.1 → XP_054176973.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  4. XM_054320994.1 → XP_054176969.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  5. XM_054320989.1 → XP_054176964.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  6. XM_054320995.1 → XP_054176970.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  7. XM_054320991.1 → XP_054176966.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  8. XM_054320993.1 → XP_054176968.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  9. XM_054320999.1 → XP_054176974.1  zinc finger protein 793 isoform X2

  10. XM_054320990.1 → XP_054176965.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  11. XM_054320996.1 → XP_054176971.1  zinc finger protein 793 isoform X1

    UniProtKB/Swiss-Prot
    E9PGN4, Q6ZN11, Q7Z3Q9

  12. XM_054321000.1 → XP_054176975.1  zinc finger protein 793 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN11.2 GenPept UniProtKB/Swiss-Prot:Q6ZN11

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