aay astray [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aayprovided by FlyBase
Official Full Name: astrayprovided by FlyBase
Primary source: FLYBASE:FBgn0023129
Locus tag: Dmel_CG3705
See related: AllianceGenome:FB:FBgn0023129
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0423/14; 24661601; Aay; anon-WO0172774.117; CG3705; Dmel\CG3705
Summary: Predicted to enable L-phosphoserine phosphatase activity and magnesium ion binding activity. Involved in behavioral response to ethanol. Predicted to be active in cytoplasm. Is expressed in several structures, including ectoderm anlage; extended germ band embryo; germ layer; gut; and sensory nervous system primordium. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9423253..9424781)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9416353..9417881)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-phosphoserine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-phosphoserine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables L-phosphoserine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-serine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_524001.2

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The following sections contain reference sequences that belong to a specific genome build. Explain