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GDPGP1 GDP-D-glucose phosphorylase 1 [ Homo sapiens (human) ]

Gene ID: 390637, updated on 5-Mar-2024

Summary

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Official Symbol
GDPGP1provided by HGNC
Official Full Name
GDP-D-glucose phosphorylase 1provided by HGNC
Primary source
HGNC:HGNC:34360
See related
Ensembl:ENSG00000183208 MIM:619240; AllianceGenome:HGNC:34360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VTC2; C15orf58
Summary
Enables GDP-D-glucose phosphorylase activity. Involved in glucose metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 1.5), testis (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

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See GDPGP1 in Genome Data Viewer
Location:
15q26.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90234209..90245811)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87990216..88001816)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90777441..90789043)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90717667-90718167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90721295-90722200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90727462-90728195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10067 Neighboring gene semaphorin 4B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90744110-90745081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10068 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:90754487-90755686 Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90755750-90755924 Neighboring gene Sharpr-MPRA regulatory region 13535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90764595-90765433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6818 Neighboring gene calcium and integrin binding 1 Neighboring gene tubulin tyrosine ligase like 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90807916-90808887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90808888-90809858 Neighboring gene neugrin, neurite outgrowth associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. Adler LN, et al. J Biol Chem, 2011 Jun 17. PMID 21507950, Free PMC Article
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  3. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article
  4. Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery. Havugimana PC, et al. Nat Commun, 2022 Jul 13. PMID 35831314, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C15orf58 in humans and C10F3.4 in C. elegans display GDP-hexose phosphorylase activity but the major reaction catalyzed by these enzymes is the phosphorolysis of GDP-D-glucose to GDP and D-glucose 1-phosphate
    Title: A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP-D-glucose phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-D-glucose phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
GDP-D-glucose phosphorylase 1
Names
GDP-D-glucose phosphorylase C15orf58
NP_001013679.2
NP_001309740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013657.3 → NP_001013679.2  GDP-D-glucose phosphorylase 1

    See identical proteins and their annotated locations for NP_001013679.2

    Status: VALIDATED

    Source sequence(s)
    AC091167, BX440248
    Consensus CDS
    CCDS32327.1
    UniProtKB/Swiss-Prot
    Q6ZNW5
    Related
    ENSP00000368405.3, ENST00000329600.8
    Conserved Domains (1) summary
    cl14728
    Location:26 → 383
    DUF4922; Domain of unknown function (DUF4922)

  2. NM_001322811.2 → NP_001309740.1  GDP-D-glucose phosphorylase 1

    Status: VALIDATED

    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS32327.1
    UniProtKB/Swiss-Prot
    Q6ZNW5
    Related
    ENSP00000453822.2, ENST00000559204.6
    Conserved Domains (1) summary
    cl14728
    Location:26 → 383
    DUF4922; Domain of unknown function (DUF4922)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90234209..90245811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    87990216..88001816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNW5.2 GenPept UniProtKB/Swiss-Prot:Q6ZNW5

Gene LinkOut

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