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IGHV1OR21-1 immunoglobulin heavy variable 1/OR21-1 (non-functional) [ Homo sapiens (human) ]

Gene ID: 390530, updated on 10-Oct-2023

Summary

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Official Symbol
IGHV1OR21-1provided by HGNC
Official Full Name
immunoglobulin heavy variable 1/OR21-1 (non-functional)provided by HGNC
Primary source
HGNC:HGNC:38040
See related
Ensembl:ENSG00000277282 IMGT/GENE-DB:IGHV1/OR21-1; AllianceGenome:HGNC:38040
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
21p11.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (10649390..10649835, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (10862622..10863067)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10855487-10856405 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10854560-10855064 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10853405-10854344 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10846505-10847020 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10842671-10843548 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10838130-10838637 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10837621-10838129 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10836528-10837187 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10835867-10836527 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10833885-10834544 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10833223-10833884 Neighboring gene NANOG hESC enhancer GRCh37_chr21:10828675-10829607 Neighboring gene solute carrier family 25 member 15 pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10806014-10806975 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10806976-10807936 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10809989-10810538 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10804701-10805266 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10798959-10799488 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10805267-10805830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10791113-10792056 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10794218-10794859 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chr21:10793041-10793561 and GRCh37_chr21:10793562-10794081 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10792057-10792998 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10795186-10795980 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10795981-10796775 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10789628-10790471 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10788693-10789551 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10790482-10791066 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10785765-10786616 Neighboring gene Sharpr-MPRA regulatory region 7824 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10765276-10765789 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10764761-10765275 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10765790-10766304 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10760631-10761606 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10759655-10760630 Neighboring gene CYCS pseudogene 41 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10749518-10750230 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10748804-10749517 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10750231-10750944 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10743796-10744614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10742976-10743795 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10733773-10734290 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:10732737-10733254 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:10732217-10732736 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10727172-10727977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10726367-10727171 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10722404-10722926 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10719264-10719787 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10721357-10721880 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10721881-10722403 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10722927-10723449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10723450-10723973 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10725560-10726366 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10718741-10719263 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10717694-10718216 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10716647-10717169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10716124-10716646 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10715601-10716123 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10715077-10715600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10705779-10706632 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10697915-10698651 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10698652-10699387 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10699388-10700124 Neighboring gene OCT4 hESC enhancer GRCh37_chr21:14353861-14354362 Neighboring gene ankyrin repeat domain 30B pseudogene 2 Neighboring gene RNA, U6 small nuclear 614, pseudogene Neighboring gene vomeronasal 1 receptor 109 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IgE transcripts in the circulation of allergic children reflect a classical antigen-driven B cell response and not a superantigen-like activation. Kerzel S, et al. J Immunol, 2010 Aug 15. PMID 20660349
  2. A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Humphries CG, et al. Nature, 1988 Feb 4. PMID 3123998
  3. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. Tomlinson IM, et al. J Mol Biol, 1992 Oct 5. PMID 1404388
  4. The DNA sequence of human chromosome 21. Hattori M, et al. Nature, 2000 May 18. PMID 10830953

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

  • IGHV1/OR21-1
  • immunoglobulin heavy variable 1/OR21-1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011680.1 

    Range
    101..546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    10649390..10649835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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