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LAIR2 leukocyte associated immunoglobulin like receptor 2 [ Homo sapiens (human) ]

Gene ID: 3904, updated on 11-Apr-2024

Summary

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Official Symbol
LAIR2provided by HGNC
Official Full Name
leukocyte associated immunoglobulin like receptor 2provided by HGNC
Primary source
HGNC:HGNC:6478
See related
Ensembl:ENSG00000167618 MIM:602993; AllianceGenome:HGNC:6478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD306
Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Expression
Biased expression in placenta (RPKM 4.7), lymph node (RPKM 0.9) and 3 other tissues See more
Orthologs
all
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Genomic context

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See LAIR2 in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54502831..54510687)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57596177..57604033)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55014047..55021897)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster member 8 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55018677-55019177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55020667-55021482 Neighboring gene uncharacterized LOC105372460 Neighboring gene MPRA-validated peak3555 silencer Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human-specific LAIR2 contributes to the high invasiveness of human extravillous trophoblast cells. Liu J, et al. Reprod Biol, 2019 Sep. PMID 31548102
  2. Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2. Olde Nordkamp MJ, et al. J Innate Immun, 2014. PMID 24192271, Free PMC Article
  3. LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion. Founds SA, et al. Placenta, 2013 Mar. PMID 23332415
  4. Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. Lenting PJ, et al. PLoS One, 2010 Aug 13. PMID 20730098, Free PMC Article
  5. Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism. Elsayed OM, et al. Sci Rep, 2023 Jan 2. PMID 36593237, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dissecting T-cell heterogeneity in esophageal squamous cell carcinoma reveals the potential role of LAIR2 in antitumor immunity.
    Title: Dissecting T-cell heterogeneity in esophageal squamous cell carcinoma reveals the potential role of LAIR2 in antitumor immunity.
  2. Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.
    Title: Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.
  3. PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology.
    Title: PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology.
  4. These data suggest that species-specific genes are pivotal to the evolution of a more aggressive human placenta to match the physiological demands of human development.
    Title: Human-specific LAIR2 contributes to the high invasiveness of human extravillous trophoblast cells.
  5. genetic polymorphism is associated with pemphigus foliaceus
    Title: Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation.
  6. We suggest that LAIR1 and LAIR2 genetic variants are associated with regulation of gene expression and variable pemphigus foliaceus susceptibility, and show indirect association of LAIR2 differential mRNA expression with pemphigus foliaceus pathogenesis.
    Title: Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.
  7. recombinant LAIR-2-Fc inhibits complement-mediated lysis of cells sensitized with anti-HLA antibodies
    Title: Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.
  8. the presence of high LAIR-2 levels in 74/80 sera from patients with autoimmune thyroid diseases
    Title: Serum LAIR-2 is increased in autoimmune thyroid diseases.
  9. LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion
    Title: LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion.
  10. Two markers in two different genes (CNOT3 and LAIR2) showed significant association with ankylosing spondylitis.
    Title: A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC71634

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte-associated immunoglobulin-like receptor 2
Names
LAIR-2
leukocyte-associated Ig-like receptor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002288.6 → NP_002279.2  leukocyte-associated immunoglobulin-like receptor 2 isoform a precursor

    See identical proteins and their annotated locations for NP_002279.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC245036, AI262718, BC069366, BX106365
    Consensus CDS
    CCDS12897.1
    UniProtKB/Swiss-Prot
    Q6ISS4, Q6PEZ4
    Related
    ENSP00000301202.2, ENST00000301202.7
    Conserved Domains (1) summary
    cl11960
    Location:27 → 120
    Ig; Immunoglobulin domain

  2. NM_021270.5 → NP_067154.1  leukocyte-associated immunoglobulin-like receptor 2 isoform b precursor

    See identical proteins and their annotated locations for NP_067154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) which is shorter compared to isoform a.
    Source sequence(s)
    AC245036, AF013250, BX106365
    Consensus CDS
    CCDS12898.1
    UniProtKB/TrEMBL
    A0A0G2JN10
    Related
    ENSP00000301203.2, ENST00000351841.2
    Conserved Domains (2) summary
    smart00410
    Location:35 → 101
    IG_like; Immunoglobulin like
    cl11960
    Location:27 → 120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54502831..54510687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526961.3 → XP_011525263.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011525263.1

    Conserved Domains (2) summary
    smart00410
    Location:23 → 89
    IG_like; Immunoglobulin like
    cl11960
    Location:15 → 108
    Ig; Immunoglobulin domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    409036..416888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329681.1 → XP_054185656.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    407546..415405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331512.1 → XP_054187487.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    485161..493011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333653.1 → XP_054189628.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57596177..57604033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320988.1 → XP_054176963.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ISS4.1 GenPept UniProtKB/Swiss-Prot:Q6ISS4

Gene LinkOut

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