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CSAG3 CSAG family member 3 [ Homo sapiens (human) ]

Gene ID: 389903, updated on 10-Oct-2023

Summary

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Official Symbol
CSAG3provided by HGNC
Official Full Name
CSAG family member 3provided by HGNC
Primary source
HGNC:HGNC:26237
See related
Ensembl:ENSG00000268916 MIM:301097; AllianceGenome:HGNC:26237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSAG3A; CT24.2
Summary
Predicted to be involved in response to xenobiotic stimulus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.6), lymph node (RPKM 1.1) and 5 other tissues See more
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Genomic context

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Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152753921..152760219)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151020472..151026772)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_003871103.3 (187904..194202)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:151902449-151903648 Neighboring gene MAGE family member A12 Neighboring gene CSAG family member 4 (pseudogene) Neighboring gene MAGE family member A2 Neighboring gene MAGE family member A6 Neighboring gene MAGEA6 divergent transcript Neighboring gene MAGE family member A4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. Fourcade J, et al. J Immunol, 2010 Jun 15. PMID 20483736, Free PMC Article
  2. Coordinated expression of clustered cancer/testis genes encoded in a large inverted repeat DNA structure. Bredenbeck A, et al. Gene, 2008 May 31. PMID 18395366
  3. Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients. Materna V, et al. Virchows Arch, 2007 Feb. PMID 17216190
  4. Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers. Janjic B, et al. J Immunol, 2006 Aug 15. PMID 16888034
  5. Expression of the TRAG-3 gene in human esophageal cancer: the frequent synchronous expression of MAGE-3 gene. Ohta M, et al. Oncol Rep, 2006 Jun. PMID 16685391

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC17065, MGC149851, MGC149852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to xenobiotic stimulus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
chondrosarcoma-associated gene 2/3 protein
Names
CSAG family, member 3A
cancer/testis antigen 24.2
taxol resistance associated gene 3
taxol-resistant-associated gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129826.3 → NP_001123298.1  chondrosarcoma-associated gene 2/3 protein isoform a

    See identical proteins and their annotated locations for NP_001123298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as TRAG-3L) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC244102
    UniProtKB/Swiss-Prot
    O75605, Q0VDC3, Q96IU8, Q9Y5P2
    Related
    ENSP00000491011.1, ENST00000599845.3

  2. NM_001129828.3 → NP_001123300.1  chondrosarcoma-associated gene 2/3 protein isoform b

    See identical proteins and their annotated locations for NP_001123300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as TRAG-3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC244102, BC007228, BC119735
    UniProtKB/Swiss-Prot
    Q9Y5P2
    Related
    ENSP00000492276.1, ENST00000638835.1

RNA

  1. NR_130638.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC244102, BC007228
    Related
    ENST00000617158.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152753921..152760219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452379.2 → XP_024308147.1  chondrosarcoma-associated gene 2/3 protein isoform X1

    UniProtKB/Swiss-Prot
    O75605, Q0VDC3, Q96IU8, Q9Y5P2

  2. XM_047442103.1 → XP_047298059.1  chondrosarcoma-associated gene 2/3 protein isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791818.1 Reference GRCh38.p14 PATCHES

    Range
    323392..329684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151020472..151026772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327046.1 → XP_054183021.1  chondrosarcoma-associated gene 2/3 protein isoform X1

    UniProtKB/TrEMBL
    A0A1W2PPV0

  2. XM_054327047.1 → XP_054183022.1  chondrosarcoma-associated gene 2/3 protein isoform X2

    UniProtKB/TrEMBL
    A0A1W2PQG5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203311.1: Suppressed sequence

    Description
    NM_203311.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5P2.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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