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rhea [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38978, updated on 11-Apr-2024

Summary

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Official Symbol
rheaprovided by FlyBase
Primary source
FLYBASE:FBgn0260442
Locus tag
Dmel_CG6831
See related
AllianceGenome:FB:FBgn0260442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6831; CT21159; Dmel\CG6831; Rhea; talin; Talin; tendrils; Tln
Old locus tag
CG6831
Summary
Enables integrin binding activity. Involved in several processes, including border follicle cell migration; germ-band shortening; and post-embryonic animal organ development. Located in focal adhesion. Is expressed in several structures, including adult heart; embryonic/larval midgut primordium; muscle attachment site; spermatozoon; and wing disc. Orthologous to several human genes including TLN2 (talin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
66D6-66D7; 3-26 cM
Exon count:
22
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8545001..8574409)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8538101..8567509)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene fear-of-intimacy Neighboring gene ergic53 Neighboring gene long non-coding RNA:CR43910 Neighboring gene mir-190 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Negative elongation factor E Neighboring gene Ribosomal protein L14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Talin - the master of integrin adhesions. Klapholz B, et al. J Cell Sci, 2017 Aug 1. PMID 28701514
  2. Crystal structure of the talin integrin binding domain 2. Cheung TY, et al. J Mol Biol, 2009 Apr 10. PMID 19340939
  3. Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin. Senetar MA, et al. Gene, 2005 Dec 5. PMID 16216449
  4. Talin's second persona. Tepass U, et al. Nat Cell Biol, 2005 May. PMID 15867924
  5. Evolution at the subgene level: domain rearrangements in the Drosophila phylogeny. Wu YC, et al. Mol Biol Evol, 2012 Feb. PMID 21900599, Free PMC Article

See all (225) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that Talin phosphorylation by Slik plays an important role in fine-tuning Talin recruitment to integrin adhesion sites and maintaining muscle attachment.
    Title: Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila.
  2. Demonstrate a continuous requirement for Talin during heart growth to maintain one-to-one apposition of myofibril ends between cardiomyocytes. Retracted myofibrils cannot regenerate appositions to adjacent cells after restoration of Talin expression.
    Title: Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila.
  3. The different arrangements of the talin molecule relative to integrins suggest that talin is able to sense different force vectors, either parallel or perpendicular to the membrane.
    Title: Alternative mechanisms for talin to mediate integrin function.
  4. Talin provides instructive cues to position the luminal domain and coordinate the actin cytoskeleton during Drosophila heart lumen development
    Title: Talin is required to position and expand the luminal domain of the Drosophila heart tube.
  5. We propose that the talin head domain is essential for regulating integrin avidity in Drosophila and that this is crucial for integrin-mediated adhesion during animal development.
    Title: The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
  6. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor
    Title: Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
  7. talin integrin binding sites reinforce integrin attachment to the extracellular matrix and reinforce the link between integrins and the intracellular adhesion complex
    Title: In vivo functional analysis reveals specific roles for the integrin-binding sites of talin.
  8. Data show that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo.
    Title: Distinct developmental roles for direct and indirect talin-mediated linkage to actin.
  9. crystal structure of the talin IBS2 domain, which forms a five-helix bundle
    Title: Crystal structure of the talin integrin binding domain 2.
  10. Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required.
    Title: Multiple factors contribute to integrin-talin interactions in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiac muscle cell-cardiac muscle cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system HMP PubMed 
involved_in maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal branching, open tracheal system HMP PubMed 
Component Evidence Code Pubs
located_in Z disc HDA PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rhea
Names
CG6831-PB
CG6831-PC
CG6831-PD
CG6831-PE
CG6831-PF
CG6831-PG
CG6831-PH
CG6831-PI
rhea-PB
rhea-PC
rhea-PD
rhea-PE
rhea-PF
rhea-PG
rhea-PH
rhea-PI
talin
tendrils

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8545001..8574409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259745.2 → NP_001246674.1  rhea, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSL8
    Conserved Domains (12) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam01608
    Location:2392 → 2534
    I_LWEQ; I/LWEQ domain
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain

  2. NM_001274658.1 → NP_001261587.1  rhea, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBW9
    Conserved Domains (12) summary
    cd12150
    Location:1640 → 1811
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1673 → 1984
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:853 → 1014
    Vinculin; Vinculin family
    pfam01608
    Location:2371 → 2513
    I_LWEQ; I/LWEQ domain
    pfam08913
    Location:1838 → 1961
    VBS; Vinculin Binding Site
    pfam09141
    Location:489 → 647
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:665 → 757
    I_LWEQ; I/LWEQ domain

  3. NM_001259746.2 → NP_001246675.1  rhea, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246675.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDM3
    Conserved Domains (11) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain

  4. NM_001274659.1 → NP_001261588.1  rhea, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEJ8
    Conserved Domains (12) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam01608
    Location:2392 → 2534
    I_LWEQ; I/LWEQ domain
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain

  5. NM_001274660.1 → NP_001261589.1  rhea, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF06
    Conserved Domains (5) summary
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM

  6. NM_001259747.2 → NP_001246676.1  rhea, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246676.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDM3
    Conserved Domains (11) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain

  7. NM_001274657.1 → NP_001261586.1  rhea, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSL8
    Conserved Domains (12) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam01608
    Location:2392 → 2534
    I_LWEQ; I/LWEQ domain
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain

  8. NM_139981.4 → NP_648238.1  rhea, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648238.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSL8
    Related
    FBpp0305318
    Conserved Domains (12) summary
    cd12150
    Location:1661 → 1832
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 322
    B41; Band 4.1 homologues
    COG0840
    Location:1694 → 2005
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd10569
    Location:318 → 409
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:215 → 322
    FERM_M; FERM central domain
    pfam01044
    Location:874 → 1035
    Vinculin; Vinculin family
    pfam01608
    Location:2392 → 2534
    I_LWEQ; I/LWEQ domain
    pfam08913
    Location:1859 → 1982
    VBS; Vinculin Binding Site
    pfam09141
    Location:510 → 668
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 147
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:686 → 778
    I_LWEQ; I/LWEQ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDM3 M9NDM3
M9PBW9 M9PBW9
M9PEJ8 M9PEJ8
M9PF06 M9PF06
Q960C2 Q960C2
Q9VSL8 Q9VSL8

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