MIR99AHG mir-99a-let-7c cluster host gene [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR99AHGprovided by HGNC
Official Full Name: mir-99a-let-7c cluster host geneprovided by HGNC
Primary source: HGNC:HGNC:1274
See related: Ensembl:ENSG00000215386 MIM:615964; AllianceGenome:HGNC:1274
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MONC; DILA1; C21orf34; C21orf35; LINC00478
Expression: Broad expression in brain (RPKM 3.1), ovary (RPKM 3.0) and 17 other tissues See more
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Genomic context

Location:: 21q21.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (16070488..16631727)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (14425873..14987212)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (17442808..18004046)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression.
Title: A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression.
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells.
Title: The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells.
LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets.
Title: LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets.
Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of Mycobacterium tuberculosis.
Title: Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of Mycobacterium tuberculosis.
MIR99AHG is a noncoding tumor suppressor gene in lung adenocarcinoma.
Title: MIR99AHG is a noncoding tumor suppressor gene in lung adenocarcinoma.
This study reveals an unprecedented function of long non-coding RNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia.
Title: LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-36273 (e-PCR)
- UniSTS:77570

D21S173 (e-PCR)
- UniSTS:148741

G34566 (e-PCR)
- UniSTS:21267

RH93002 (e-PCR)
- UniSTS:85293

SHGC-104918 (e-PCR)
- UniSTS:169015

SHGC-110244 (e-PCR)
- UniSTS:167737

RH45651 (e-PCR)
- UniSTS:87106

RH65194 (e-PCR)
- UniSTS:92256

D21S1886 (e-PCR), detects polymorphism
- UniSTS:34931

D21S1962 (e-PCR)
- UniSTS:38809

SHGC-52033 (e-PCR)
- UniSTS:38810

RH91873 (e-PCR)
- UniSTS:85659

G59859 (e-PCR)
- UniSTS:137143

G35305 (e-PCR)
- UniSTS:51136

RH65394 (e-PCR)
- UniSTS:91079

SHGC-112012 (e-PCR)
- UniSTS:183534

Other Names

Cyclin D1-interacting long noncoding RNA 1
long intergenic non-protein coding RNA 478
megakaryocytic oncogenic non-coding RNA
mir-99a-let-7c cluster host gene (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.