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TMEM81 transmembrane protein 81 [ Homo sapiens (human) ]

Gene ID: 388730, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM81provided by HGNC
Official Full Name
transmembrane protein 81provided by HGNC
Primary source
HGNC:HGNC:32349
See related
Ensembl:ENSG00000174529 AllianceGenome:HGNC:32349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HC3107; UNQ2788; KVLA2788
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
mouse all
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Genomic context

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See TMEM81 in Genome Data Viewer
Location:
1q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205083129..205084460, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204347508..204348839, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205052257..205053588, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurofascin Neighboring gene ribosomal protein L13a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204981530-204982083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204983191-204983742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204987113-204987910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204987911-204988706 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:204994888-204995728 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 1:205012106 and 1:205012198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205016337-205016841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205023369-205024096 Neighboring gene contactin 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:205041546-205042745 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205044866 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 1:205044354 and 1:205044416 Neighboring gene Sharpr-MPRA regulatory region 1805 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205074018 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205075359 Neighboring gene RB binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene glycogenin 2 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205089166-205089724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2375 Neighboring gene Sharpr-MPRA regulatory region 3970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205101461-205101961 Neighboring gene signal peptidase complex subunit 1-like Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205104550 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:205106956-205107504

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC75217

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203376.2 → NP_976310.1  transmembrane protein 81 precursor

    See identical proteins and their annotated locations for NP_976310.1

    Status: VALIDATED

    Source sequence(s)
    AY359081, BC061592
    Consensus CDS
    CCDS1450.1
    UniProtKB/Swiss-Prot
    Q6P7N7, Q6UVZ4
    UniProtKB/TrEMBL
    B4E0M0
    Related
    ENSP00000356135.3, ENST00000367167.4
    Conserved Domains (1) summary
    cl11960
    Location:93 → 163
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205083129..205084460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    204347508..204348839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7N7.1 GenPept UniProtKB/Swiss-Prot:Q6P7N7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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