U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IGFL3 IGF like family member 3 [ Homo sapiens (human) ]

Gene ID: 388555, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
IGFL3provided by HGNC
Official Full Name
IGF like family member 3provided by HGNC
Primary source
HGNC:HGNC:32930
See related
Ensembl:ENSG00000188624 MIM:610546; AllianceGenome:HGNC:32930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ483
Summary
IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46120067..46124688, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48947474..48952095, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46623324..46627945, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 4 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46636065-46636896 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:46636897-46637728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46637729-46638559 Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:46662347-46663546 Neighboring gene uncharacterized LOC105372424 Neighboring gene NANOG hESC enhancer GRCh37_chr19:46673889-46674439

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
  2. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. Lobito AA, et al. J Biol Chem, 2011 May 27. PMID 21454693, Free PMC Article
  3. Human gingiva transcriptome during wound healing. Wang Y, et al. J Clin Periodontol, 2017 Apr. PMID 28005267
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
insulin growth factor-like family member 3
Names
RPRC483

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207393.2 → NP_997276.1  insulin growth factor-like family member 3 precursor

    See identical proteins and their annotated locations for NP_997276.1

    Status: VALIDATED

    Source sequence(s)
    AC007785, AY358434
    Consensus CDS
    CCDS33058.1
    UniProtKB/Swiss-Prot
    Q6UXB1
    Related
    ENSP00000344860.2, ENST00000341415.3
    Conserved Domains (1) summary
    pfam14653
    Location:33 → 115
    IGFL; Insulin growth factor-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46120067..46124688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526953.3 → XP_011525255.1  insulin growth factor-like family member 3 isoform X1

    Conserved Domains (1) summary
    pfam14653
    Location:27 → 115
    IGFL; Insulin growth factor-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48947474..48952095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320963.1 → XP_054176938.1  insulin growth factor-like family member 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXB1.1 GenPept UniProtKB/Swiss-Prot:Q6UXB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous