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RPSA2 ribosomal protein SA 2 [ Homo sapiens (human) ]

Gene ID: 388524, updated on 11-Apr-2024

Summary

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Official Symbol
RPSA2provided by HGNC
Official Full Name
ribosomal protein SA 2provided by HGNC
Primary source
HGNC:HGNC:36809
See related
Ensembl:ENSG00000288920 AllianceGenome:HGNC:36809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
67LR; LamR; 37LRP; LRP/LR; LBP/p40; RPSAP58; RPSA_30_1642
Expression
Ubiquitous expression in ovary (RPKM 296.8), lymph node (RPKM 201.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See RPSA2 in Genome Data Viewer
Location:
19p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23758496..23871188)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23898911..24016747)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23941298..24053990)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:23848667-23849407 Neighboring gene zinc finger protein 675 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23868450-23869420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14394 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23906366-23907280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23941373-23941891 Neighboring gene vomeronasal 1 receptor 94 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23944886-23945526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23945527-23946168 Neighboring gene zinc finger protein 681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23951857-23952358 Neighboring gene BCL2 interacting protein 3 pseudogene 39 Neighboring gene uncharacterized LOC124904677 Neighboring gene zinc finger protein 726 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078454-24078954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078955-24079455 Neighboring gene zinc finger protein 726 Neighboring gene uncharacterized LOC100505851

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV, et al. Mol Cell, 2016 Mar 17. PMID 26990986, Free PMC Article
  2. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Li Z, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29228324, Free PMC Article
  3. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables laminin binding IEA
Inferred from Electronic Annotation
more info
  
enables laminin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS2B
Names
37 kDa laminin receptor
37/67 kDa laminin receptor
40S ribosomal protein SA
40S ribosomal protein SA2
67 kDa laminin receptor
laminin receptor 1
laminin-binding protein precursor p40
ribosomal protein SA pseudogene 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355283.3 → NP_001342212.1  small ribosomal subunit protein uS2B

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Consensus CDS
    CCDS92575.1
    UniProtKB/Swiss-Prot
    A0A8I5KQE6
    UniProtKB/TrEMBL
    Q96RS2
    Related
    ENSP00000509526.1, ENST00000484897.4
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

  2. NM_001355287.3 → NP_001342216.1  small ribosomal subunit protein uS2B

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Consensus CDS
    CCDS92575.1
    UniProtKB/Swiss-Prot
    A0A8I5KQE6
    UniProtKB/TrEMBL
    Q96RS2
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

  3. NM_001387845.1 → NP_001374774.1  small ribosomal subunit protein uS2B

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Consensus CDS
    CCDS92575.1
    UniProtKB/Swiss-Prot
    A0A8I5KQE6
    UniProtKB/TrEMBL
    Q96RS2
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

  4. NM_001387846.1 → NP_001374775.1  small ribosomal subunit protein uS2B

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Consensus CDS
    CCDS92575.1
    UniProtKB/Swiss-Prot
    A0A8I5KQE6
    UniProtKB/TrEMBL
    Q96RS2
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

RNA

  1. NR_149350.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
    Source sequence(s)
    AC139769, KF495804
    Related
    ENST00000689525.1

  2. NR_149351.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
    Source sequence(s)
    AC139769, KF495804

  3. NR_149352.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
    Source sequence(s)
    AC139769, KF495804

  4. NR_170708.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804

  5. NR_170709.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Related
    ENST00000475499.2

  6. NR_170710.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804

  7. NR_170711.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804

  8. NR_170712.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804
    Related
    ENST00000692590.1

  9. NR_170713.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769, KF495804

  10. NR_170714.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139769

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23758496..23871188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23898911..24016747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005472.1: Suppressed sequence

    Description
    NM_001005472.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A8I5KQE6.1 GenPept UniProtKB/Swiss-Prot:A0A8I5KQE6

Gene LinkOut

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