TNFAIP8L3 TNF alpha induced protein 8 like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNFAIP8L3provided by HGNC
Official Full Name: TNF alpha induced protein 8 like 3provided by HGNC
Primary source: HGNC:HGNC:20620
See related: Ensembl:ENSG00000183578 MIM:616438; AllianceGenome:HGNC:20620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIPE3
Summary: Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in several processes, including inositol lipid-mediated signaling; positive regulation of intracellular signal transduction; and positive regulation of phosphatidylinositol 3-kinase activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in endometrium (RPKM 16.6), esophagus (RPKM 6.5) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (51056601..51105276, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (48864239..48912949, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (51348798..51397473, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive analysis of the prognostic and immunological roles of TIPE3 in Colon Cancer.
Title: Comprehensive analysis of the prognostic and immunological roles of TIPE3 in Colon Cancer.
TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction.
Title: TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction.
TIPE3 protects mice from lipopolysaccharide-induced acute lung injury.
Title: TIPE3 protects mice from lipopolysaccharide-induced acute lung injury.
Tumor necrosis factor-alpha-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer.
Title: Tumor necrosis factor-α-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer.
Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-kappaB, and STAT-3 signaling cascades.
Title: Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-κB, and STAT-3 signaling cascades.
Effects of the long and short isoforms of TIPE3 on the growth and metastasis of gastric cancer.
Title: Effects of the long and short isoforms of TIPE3 on the growth and metastasis of gastric cancer.
TNFAIP8L3 is highly expressed in human cancer cells and promotes carcinogenesis. Silence of TNFAIP8L3 diminished Gastric Cancer cells migration mediated by miR-9-5p.
Title: miR-9-5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3.
TIPE3 inhibits p38 phosphorylation and blocks p38 nuclear translocation to inhibit glioblastoma cell apoptosis.
Title: TIPE3 is a regulator of cell apoptosis in glioblastoma.
In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. (Meta-analysis)
Title: A genome-wide association study of corneal astigmatism: The CREAM Consortium.
TIPE3 downregulation correlates with its CpG island hypermethylation in several solid cancers. TIPE3 acts as a tumor suppressor in nasopharyngeal carcinoma (NPC), providing a further insight into NPC progression and representing a potential prognostic biomarker for NPC
Title: TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-85220 (e-PCR)
- UniSTS:104357

G38326 (e-PCR)
- UniSTS:6873

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol transfer activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	TAS Traceable Author Statement more info
involved_in phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 8-like protein 3

Names: TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3; tumor necrosis factor, alpha induced protein 8 like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311175.2 → NP_001298104.1 tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 2

See identical proteins and their annotated locations for NP_001298104.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC073964, AK123281, CA447540, HY052681

Consensus CDS

CCDS81881.1

UniProtKB/TrEMBL

A0A1B0GTK8

Related

ENSP00000489743.1, ENST00000637513.2

Conserved Domains (1) summary

pfam05527
Location:23 → 201

DUF758; Domain of unknown function (DUF758)
NM_207381.4 → NP_997264.2 tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1

See identical proteins and their annotated locations for NP_997264.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AY517501, CA447540

Consensus CDS

CCDS32241.1

UniProtKB/Swiss-Prot

Q5GJ75, Q6ZWD1

Related

ENSP00000328016.5, ENST00000327536.5

Conserved Domains (1) summary

pfam05527
Location:111 → 289

DUF758; Domain of unknown function (DUF758)