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FAM99A family with sequence similarity 99 member A [ Homo sapiens (human) ]

Gene ID: 387742, updated on 8-Nov-2023

Summary

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Official Symbol
FAM99Aprovided by HGNC
Official Full Name
family with sequence similarity 99 member Aprovided by HGNC
Primary source
HGNC:HGNC:32368
See related
Ensembl:ENSG00000205866 AllianceGenome:HGNC:32368
Gene type
ncRNA
RefSeq status
PREDICTED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in liver (RPKM 15.9) and placenta (RPKM 1.5) See more
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Genomic context

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Location:
11p15.5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1665599..1667856)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1749630..1751930)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1686829..1689086)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1653741-1654240 Neighboring gene keratin associated protein 5-5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1676043-1676647 Neighboring gene uncharacterized LOC124902609 Neighboring gene Sharpr-MPRA regulatory region 10567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1706195-1706964 Neighboring gene family with sequence similarity 99 member B Neighboring gene long intergenic non-protein coding RNA 2708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer. Sun M, et al. IET Syst Biol, 2023 Apr. PMID 36854891, Free PMC Article
  2. Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma. Mo M, et al. BMC Cancer, 2022 Oct 26. PMID 36289466, Free PMC Article
  3. Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance. Ge Q, et al. Blood Press Monit, 2022 Aug 1. PMID 35258024
  4. Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p. Xu B, et al. Braz J Med Biol Res, 2020. PMID 33111745, Free PMC Article
  5. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. He T, et al. Mol Med Rep, 2019 Aug. PMID 31173227

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer.
    Title: In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer.
  2. Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma.
    Title: Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma.
  3. Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance.
    Title: Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance.
  4. Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p.
    Title: Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p.
  5. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis.
    Title: lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • family with sequence similarity 99 member A (non-protein coding)

Clone Names

  • FLJ42833, DKFZp781M09150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026643.1 RNA Sequence

    Status: PREDICTED

    Source sequence(s)
    AP006285
    Related
    ENST00000382167.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1665599..1667856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791792.1 Reference GRCh38.p14 PATCHES

    Range
    405575..407832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187584.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    147836..150093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    139693..141959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1749630..1751930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014374.1: Suppressed sequence

    Description
    NM_001014374.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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