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RASL11A RAS like family 11 member A [ Homo sapiens (human) ]

Gene ID: 387496, updated on 7-Apr-2024

Summary

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Official Symbol
RASL11Aprovided by HGNC
Official Full Name
RAS like family 11 member Aprovided by HGNC
Primary source
HGNC:HGNC:23802
See related
Ensembl:ENSG00000122035 MIM:612403; AllianceGenome:HGNC:23802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 15.1), colon (RPKM 11.1) and 24 other tissues See more
Orthologs
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Genomic context

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See RASL11A in Genome Data Viewer
Location:
13q12.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (27270830..27275192)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (26491553..26495914)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27844967..27849329)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 102 Neighboring gene ribosomal protein L21 Neighboring gene small nucleolar RNA, H/ACA box 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27844429-27844929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5199 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:27909191-27910390 Neighboring gene RNA, U6 small nuclear 70, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27936491-27936992 Neighboring gene uncharacterized LOC105370126 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:27947836-27949035

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells. Wangsa D, et al. Neoplasia, 2019 Jul. PMID 31174021, Free PMC Article
  2. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. Pistoni M, et al. EMBO J, 2010 Apr 7. PMID 20168301, Free PMC Article
  3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. One gene, RASL11A, localized on chromosome band 13q12.2, escaped the copy number-induced overexpression and was reproducibly and significantly down-regulated on the mRNA and protein level (P=.0001, FDR=0.002). RASL11A expression levels were also lower in primary colorectal tumors as compared to matched normal mucosa (P=.0001, FDR=0.0001
    Title: Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
  2. In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region.
    Title: Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a.
  3. RASL11A is down-regulated in prostate tumors as measured by quantitative real-time PCR. This result suggests that this gene may have a tumor suppressor role in prostate cancer.
    Title: RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ras-like protein family member 11A
NP_001318055.1
NP_996563.1
XP_024305115.1
XP_054230491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331126.2 → NP_001318055.1  ras-like protein family member 11A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL159977
    UniProtKB/Swiss-Prot
    Q6T310
    Conserved Domains (1) summary
    cd04146
    Location:1 → 156
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

  2. NM_206827.2 → NP_996563.1  ras-like protein family member 11A isoform 1

    See identical proteins and their annotated locations for NP_996563.1

    Status: VALIDATED

    Source sequence(s)
    AL159977
    Consensus CDS
    CCDS9321.1
    UniProtKB/Swiss-Prot
    B2RN97, Q6T310
    Related
    ENSP00000241463.5, ENST00000241463.5
    Conserved Domains (1) summary
    cd04146
    Location:29 → 198
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    27270830..27275192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449347.2 → XP_024305115.1  ras-like protein family member 11A isoform X1

    Conserved Domains (1) summary
    cd04146
    Location:1 → 156
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    26491553..26495914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374516.1 → XP_054230491.1  ras-like protein family member 11A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T310.1 GenPept UniProtKB/Swiss-Prot:Q6T310

Gene LinkOut

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