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CG18586 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38659, updated on 4-Apr-2024

Summary

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Official Symbol
CG18586provided by FlyBase
Primary source
FLYBASE:FBgn0035642
Locus tag
Dmel_CG18586
See related
AllianceGenome:FB:FBgn0035642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG18586
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
64F3-64F3; 3-15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5873311..5875466)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5866411..5868566)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene krishah Neighboring gene mad2 Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase epsilon subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663
  2. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Oba Y, et al. Gene, 2004 Mar 31. PMID 15033536
  3. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Oba Y, et al. Biosci Biotechnol Biochem, 2005 Apr. PMID 15849423
  4. Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. Durham MF, et al. Nat Commun, 2014 Jul 8. PMID 25000897
  5. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG18586-PB
CG18586-PC
NP_001261453.1
NP_647993.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5873311..5875466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274524.1 → NP_001261453.1  uncharacterized protein Dmel_CG18586, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261453.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEA1
    Conserved Domains (2) summary
    COG0318
    Location:52 → 532
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    cl17068
    Location:55 → 521
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_139736.2 → NP_647993.2  uncharacterized protein Dmel_CG18586, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647993.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V535, Q9VRQ5
    Conserved Domains (2) summary
    COG0318
    Location:35 → 541
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    cl17068
    Location:55 → 530
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEA1 M9PEA1
Q9VRQ5 Q9VRQ5

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