Kng2 kininogen 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kng2provided by MGI
Official Full Name: kininogen 2provided by MGI
Primary source: MGI:MGI:3027157
See related: Ensembl:ENSMUSG00000060459 AllianceGenome:MGI:3027157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity; protease binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and negative regulation of endopeptidase activity. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 103.8), liver adult (RPKM 51.3) and 4 other tissues See more
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Genomic context

Location:: 16 B1; 16 13.82 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (22804602..22847851, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (22985852..23029101, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.
Title: Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.
Two genes, kininogen-I and kininogen-II, are located in close proximity on chromosome 16 in a head-to-head arrangement. In liver and kidney, both genes are expressed and for each gene three alternative splice variants are synthesized.
Title: Structure and expression of two kininogen genes in mice.
in the kidney K2 is strongly expressed as both HMWK and LMWK, whereas K1 is not expressed as HMWK and expressed only very weakly as LMWK
Title: A second expressed kininogen gene in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

General gene information

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Markers

D17999 (e-PCR)
- UniSTS:124760

NoName (e-PCR)
- UniSTS:489569

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kininogen 2

Names: Kininogen-II; kininogen II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102409.1 → NP_001095879.1 kininogen 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001095879.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-II, has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA086752, BC139720, BY773346, CT027991

Consensus CDS

CCDS49801.1

UniProtKB/TrEMBL

Q6S9I0

Related

ENSMUSP00000111006.3, ENSMUST00000115349.9

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain
NM_001102410.1 → NP_001095880.1 kininogen 2 isoform 3 precursor

See identical proteins and their annotated locations for NP_001095880.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA403606, BC139720, BY773346

Consensus CDS

CCDS49802.1

UniProtKB/TrEMBL

Q6S9I2

Related

ENSMUSP00000046867.7, ENSMUST00000039338.13

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain
NM_201375.2 → NP_958763.1 kininogen 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_958763.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-II.

Source sequence(s)

AA403606, BC139720, BY773346, CT027991

Consensus CDS

CCDS28072.1

UniProtKB/TrEMBL

Q6DMP4, Q6S9I3

Related

ENSMUSP00000097623.3, ENSMUST00000100046.9

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain