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ImpL2 Ecdysone-inducible gene L2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38513, updated on 26-Apr-2024

Summary

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Official Symbol
ImpL2provided by FlyBase
Official Full Name
Ecdysone-inducible gene L2provided by FlyBase
Primary source
FLYBASE:FBgn0001257
Locus tag
Dmel_CG15009
See related
AllianceGenome:FB:FBgn0001257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15009; CT34862; Dmel\CG15009; GH28; Imp-12; imp-L2; Imp-L2; IMP-L2; ImpL-2; impl2; impL2; Impl2; IMPL2
Summary
Enables insulin binding activity. Involved in several processes, including negative regulation of phosphatidylinositol 3-kinase signaling; positive regulation of entry into reproductive diapause; and regulation of insulin receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including ectoderm; ectoderm anlage; epithelium; extended germ band embryo; and gut section. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
64A10-64A10; 3-10 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4224006..4236147, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4224006..4236147, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 64Ad Neighboring gene antisense RNA:CR32252 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45738 Neighboring gene Sulfide quinone oxidoreductase Neighboring gene pavarotti

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Continuing Evolution of Insulin-like Growth Factor Signaling. Rosenzweig SA. F1000Res, 2020. PMID 32226608, Free PMC Article
  2. Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2. Pompach P, et al. Front Endocrinol (Lausanne), 2019. PMID 31649623, Free PMC Article
  3. Antidiabetes study of Spondias mombin (Linn) stem bark fractions in high-sucrose diet-induced diabetes in Drosophila melanogaster. Omoboyowa DA, et al. J Taibah Univ Med Sci, 2023 Aug. PMID 36845998, Free PMC Article
  4. Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila. Sênos Demarco R, et al. Cell Rep, 2022 Apr 19. PMID 35443165, Free PMC Article
  5. Modulatory effect of Artocarpus camansi on ILP-2, InR, and Imp-L2 genes of sucrose -induced diabetes mellitus in Drosophila melanogaster. Saliu JA, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Aug. PMID 33866007

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
    Title: Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
  2. Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
    Title: Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
  3. Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
    Title: Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
  4. Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
    Title: Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
  5. beta-sheet fold serves as a direct, high-affinity binder of hormones; likely represents an alternative hormone binding and regulatory IBP system different and evolutionarily independent from human IGFBPs
    Title: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
  6. Increased expression of ImpL2 is associated with cachexia-like wasting.
    Title: Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.
  7. Increased expression of the secreted insulin/IGF antagonist ImpL2 is associated with organ wasting.
    Title: Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
  8. Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions
    Title: Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions.
  9. role in the longevity
    Title: Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of entry into reproductive diapause IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ecdysone-inducible gene L2
Names
CG15009-PA
CG15009-PB
CG15009-PC
CG15009-PD
ImpL2-PA
ImpL2-PB
ImpL2-PC
ImpL2-PD
ecdysone-inducible gene L2
imaginal morphogenesis protein-late 2
neural and ectodermal development factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4224006..4236147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274480.1 → NP_001261409.1  Ecdysone-inducible gene L2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEL7, Q3YMW0
    Conserved Domains (1) summary
    smart00408
    Location:183 → 247
    IGc2; Immunoglobulin C-2 Type

  2. NM_079197.5 → NP_523921.3  Ecdysone-inducible gene L2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523921.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3YMW0
    Related
    FBpp0073104
    Conserved Domains (1) summary
    smart00408
    Location:186 → 250
    IGc2; Immunoglobulin C-2 Type

  3. NM_168069.2 → NP_728960.1  Ecdysone-inducible gene L2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEL7, Q3YMW0
    Related
    FBpp0073105
    Conserved Domains (1) summary
    smart00408
    Location:183 → 247
    IGc2; Immunoglobulin C-2 Type

  4. NM_168070.2 → NP_728961.2  Ecdysone-inducible gene L2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728961.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09024, Q6NLN1, Q7KV52, Q95SU7, Q9VZF7
    UniProtKB/TrEMBL
    Q3YMW0
    Related
    FBpp0073106
    Conserved Domains (1) summary
    smart00408
    Location:187 → 251
    IGc2; Immunoglobulin C-2 Type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEL7 M9PEL7
Q09024.4 Q09024
Q24364 Q24364
Q24365 Q24365
Q24366 Q24366
Q3YMW0 Q3YMW0

Gene LinkOut

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