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Adam34l a disintegrin and metallopeptidase domain 34 like [ Mus musculus (house mouse) ]

Gene ID: 384813, updated on 8-Feb-2024

Summary

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Official Symbol
Adam34lprovided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 34 likeprovided by MGI
Primary source
MGI:MGI:3647273
See related
Ensembl:ENSMUSG00000050190 AllianceGenome:MGI:3647273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5346; EG384813
Summary
Predicted to be involved in male gonad development. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 2.0) See more
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Genomic context

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Location:
8 A4; 8 24.05 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (44077926..44156461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43624889..43703424, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 26A Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene Neighboring gene a disintegrin and metallopeptidase domain 34 Neighboring gene predicted gene 5347 Neighboring gene predicted gene 45488 Neighboring gene STARR-seq mESC enhancer starr_21337 Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene peptidyl prolyl isomerase H pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
a disintegrin and metallopeptidase domain 34 like
Names
a disintegrin and metallopeptidase domain 26B pseudogene
testase 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025240.2 → NP_001020411.1  a disintegrin and metallopeptidase domain 34 like

    See identical proteins and their annotated locations for NP_001020411.1

    Status: VALIDATED

    Source sequence(s)
    AC125369, AC131115
    Consensus CDS
    CCDS40332.1
    UniProtKB/TrEMBL
    Q7M766
    Related
    ENSMUSP00000058858.4, ENSMUST00000056023.5
    Conserved Domains (4) summary
    smart00608
    Location:492 → 628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:207 → 395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416 → 488
    Disintegrin
    pfam01562
    Location:41 → 159
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    44077926..44156461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019558.1: Suppressed sequence

    Description
    NG_019558.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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