U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tldc2 TBC/LysM associated domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 383766, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tldc2provided by MGI
Official Full Name
TBC/LysM associated domain containing 2provided by MGI
Primary source
MGI:MGI:2686178
See related
Ensembl:ENSMUSG00000074628 AllianceGenome:MGI:2686178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1332
Summary
Acts upstream of or within negative regulation of oxidative stress-induced neuron death. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human TLDC2 (TBC/LysM-associated domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 1.6), large intestine adult (RPKM 0.9) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tldc2 in Genome Data Viewer
Location:
2 H1; 2 77.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156918542..156938868)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157076627..157096948)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component Neighboring gene microtubule crosslinking factor 2 Neighboring gene STARR-seq mESC enhancer starr_06195 Neighboring gene STARR-seq mESC enhancer starr_06196 Neighboring gene SAM domain and HD domain, 1 Neighboring gene STARR-seq mESC enhancer starr_06197 Neighboring gene STARR-positive B cell enhancer ABC_E6008 Neighboring gene STARR-positive B cell enhancer ABC_E7876 Neighboring gene STARR-positive B cell enhancer ABC_E2649 Neighboring gene STARR-seq mESC enhancer starr_06198 Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. Finelli MJ, et al. J Biol Chem, 2016 Feb 5. PMID 26668325, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TLD domain-containing protein 2
Names
TBC/LysM-associated domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177439.2 → NP_001170910.1  TLD domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AL669828
    Consensus CDS
    CCDS50782.1
    UniProtKB/Swiss-Prot
    A2ACG1
    UniProtKB/TrEMBL
    E9PZS3
    Related
    ENSMUSP00000129278.2, ENSMUST00000166140.8
    Conserved Domains (1) summary
    smart00584
    Location:50 → 212
    TLDc; domain in TBC and LysM domain containing proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156918542..156938868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499838.5 → XP_006499901.1  TLD domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    smart00584
    Location:115 → 261
    TLDc; domain in TBC and LysM domain containing proteins

  2. XM_006499836.4 → XP_006499899.1  TLD domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499899.1

    Conserved Domains (1) summary
    smart00584
    Location:115 → 261
    TLDc; domain in TBC and LysM domain containing proteins

  3. XM_006499837.4 → XP_006499900.1  TLD domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499900.1

    Conserved Domains (1) summary
    smart00584
    Location:115 → 261
    TLDc; domain in TBC and LysM domain containing proteins

  4. XM_006499841.4 → XP_006499904.1  TLD domain-containing protein 2 isoform X6

    UniProtKB/Swiss-Prot
    A2ACG1
    Conserved Domains (1) summary
    smart00584
    Location:72 → 218
    TLDc; domain in TBC and LysM domain containing proteins

  5. XM_036162348.1 → XP_036018241.1  TLD domain-containing protein 2 isoform X7

    UniProtKB/Swiss-Prot
    A2ACG1
    UniProtKB/TrEMBL
    E9PZS3
    Conserved Domains (1) summary
    smart00584
    Location:50 → 212
    TLDc; domain in TBC and LysM domain containing proteins

  6. XM_006499840.4 → XP_006499903.1  TLD domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    smart00584
    Location:115 → 216
    TLDc; domain in TBC and LysM domain containing proteins

  7. XM_011239652.3 → XP_011237954.1  TLD domain-containing protein 2 isoform X8

    Conserved Domains (1) summary
    cl02144
    Location:115 → 190
    TLD

  8. XM_030251822.2 → XP_030107682.1  TLD domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    smart00584
    Location:115 → 261
    TLDc; domain in TBC and LysM domain containing proteins

  9. XM_036162347.1 → XP_036018240.1  TLD domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    smart00584
    Location:93 → 210
    TLDc; domain in TBC and LysM domain containing proteins

  10. XM_006499839.4 → XP_006499902.1  TLD domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    smart00584
    Location:93 → 255
    TLDc; domain in TBC and LysM domain containing proteins

  11. XM_006499843.5 → XP_006499906.1  TLD domain-containing protein 2 isoform X9

    UniProtKB/Swiss-Prot
    A2ACG1
    Conserved Domains (1) summary
    smart00584
    Location:58 → 204
    TLDc; domain in TBC and LysM domain containing proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ACG1.1 GenPept UniProtKB/Swiss-Prot:A2ACG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous