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Serpinb3b serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B [ Mus musculus (house mouse) ]

Gene ID: 383548, updated on 9-Dec-2024

Summary

Official Symbol
Serpinb3bprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3Bprovided by MGI
Primary source
MGI:MGI:2683293
See related
Ensembl:ENSMUSG00000073602 AllianceGenome:MGI:2683293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scca2-rs; Scca2-rs1
Summary
Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and extracellular exosome. Predicted to be active in extracellular space. Is expressed in genital tubercle and gonad. Orthologous to human SERPINB3 (serpin family B member 3) and SERPINB4 (serpin family B member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Serpinb3b in Genome Data Viewer
Location:
1 E2.1; 1 50.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107081691..107088844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107153961..107161114, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D Neighboring gene STARR-seq mESC enhancer starr_01865 Neighboring gene STARR-seq mESC enhancer starr_01866 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D pseudogene Neighboring gene STARR-seq mESC enhancer starr_01867 Neighboring gene 40S ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • MGC118408

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasmic vesicle  
located_in cytosol  
located_in extracellular exosome  
is_active_in extracellular space  
located_in nucleus  
located_in plasma membrane  

General protein information

Preferred Names
serine (or cysteine) proteinase inhibitor, clade b, member 3b
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3B
squamous cell carcinoma antigen 2 related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198680.2NP_941373.1  serine (or cysteine) proteinase inhibitor, clade b, member 3b

    See identical proteins and their annotated locations for NP_941373.1

    Status: PROVISIONAL

    Source sequence(s)
    AK003220
    Consensus CDS
    CCDS15216.1
    UniProtKB/TrEMBL
    Q6UKZ2, Q9D1Q5
    Related
    ENSMUSP00000083901.5, ENSMUST00000086694.11
    Conserved Domains (1) summary
    cl00137
    Location:6387
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    107081691..107088844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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