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Ypel5 yippee like 5 [ Mus musculus (house mouse) ]

Gene ID: 383295, updated on 5-Mar-2024

Summary

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Official Symbol
Ypel5provided by MGI
Official Full Name
yippee like 5provided by MGI
Primary source
MGI:MGI:1916937
See related
Ensembl:ENSMUSG00000039770 AllianceGenome:MGI:1916937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-127; 2310076K21Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be part of ubiquitin ligase complex. Is expressed in brain; intestine; liver; and neural retina. Orthologous to human YPEL5 (yippee like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.3; 17 44.7 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73143623..73157439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (72836628..72850444)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene anaplastic lymphoma kinase Neighboring gene STARR-seq mESC enhancer starr_43183 Neighboring gene STARR-seq mESC enhancer starr_43185 Neighboring gene predicted gene, 53975 Neighboring gene STARR-seq mESC enhancer starr_43186 Neighboring gene predicted gene, 53976 Neighboring gene STARR-positive B cell enhancer ABC_E5626 Neighboring gene STARR-seq mESC enhancer starr_43189 Neighboring gene STARR-positive B cell enhancer ABC_E171 Neighboring gene STARR-seq mESC enhancer starr_43192 Neighboring gene STARR-positive B cell enhancer ABC_E4224 Neighboring gene predicted gene, 30256 Neighboring gene predicted gene, 30375

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1. Jeidane S, et al. Cell Rep, 2016 Oct 4. PMID 27705791
  2. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  3. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ypel5 is a negative regulator of IFNB1 production and innate immune responses that interacts functionally and physically with TBK1/IKBKE kinases
    Title: Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein yippee-like 5
Names
yippee protein homolog
NP_001344297.1
NP_001344298.1
NP_001344299.1
NP_001344300.1
NP_081442.1
XP_006524601.1
XP_006524602.1
XP_030105745.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357368.1 → NP_001344297.1  protein yippee-like 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163036, BQ176693
    Consensus CDS
    CCDS28963.1
    UniProtKB/Swiss-Prot
    P62700, Q543T4
    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Related
    ENSMUSP00000156501.2, ENSMUST00000233210.2
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. NM_001357369.1 → NP_001344298.1  protein yippee-like 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163036, BQ176693
    Consensus CDS
    CCDS28963.1
    UniProtKB/Swiss-Prot
    P62700, Q543T4
    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Related
    ENSMUSP00000156450.2, ENSMUST00000233886.2
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  3. NM_001357370.1 → NP_001344299.1  protein yippee-like 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163036, BQ176693
    Consensus CDS
    CCDS28963.1
    UniProtKB/Swiss-Prot
    P62700, Q543T4
    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  4. NM_001357371.1 → NP_001344300.1  protein yippee-like 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163036, BQ176693
    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Conserved Domains (1) summary
    cl13152
    Location:32 → 124
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  5. NM_027166.6 → NP_081442.1  protein yippee-like 5 isoform 1

    See identical proteins and their annotated locations for NP_081442.1

    Status: VALIDATED

    Source sequence(s)
    AC163036, AK169241, BQ176693, CA556143
    Consensus CDS
    CCDS28963.1
    UniProtKB/Swiss-Prot
    P62700, Q543T4
    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Related
    ENSMUSP00000037764.6, ENSMUST00000045174.7
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    73143623..73157439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524539.3 → XP_006524602.1  protein yippee-like 5 isoform X1

    See identical proteins and their annotated locations for XP_006524602.1

    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Conserved Domains (1) summary
    cl13152
    Location:32 → 124
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. XM_030249885.2 → XP_030105745.1  protein yippee-like 5 isoform X1

    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Conserved Domains (1) summary
    cl13152
    Location:32 → 124
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  3. XM_006524538.1 → XP_006524601.1  protein yippee-like 5 isoform X1

    See identical proteins and their annotated locations for XP_006524601.1

    UniProtKB/TrEMBL
    Q3TDV0, Q3TMG7, Q65Z92
    Conserved Domains (1) summary
    cl13152
    Location:32 → 124
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62700.1 GenPept UniProtKB/Swiss-Prot:P62700

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