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Mtx3 metaxin 3 [ Mus musculus (house mouse) ]

Gene ID: 382793, updated on 5-Mar-2024

Summary

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Official Symbol
Mtx3provided by MGI
Official Full Name
metaxin 3provided by MGI
Primary source
MGI:MGI:2686040
See related
Ensembl:ENSMUSG00000021704 AllianceGenome:MGI:2686040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1194; Gm6514; EG624619; 4930470O13Rik
Summary
Predicted to be involved in mitochondrion organization. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX3 (metaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.2), cerebellum adult (RPKM 6.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C3; 13 47.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92981251..92994738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92844743..92858230)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10807 Neighboring gene STARR-seq mESC enhancer starr_35273 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene Neighboring gene thrombospondin 4 Neighboring gene STARR-seq mESC enhancer starr_35274 Neighboring gene predicted gene, 31630 Neighboring gene STARR-positive B cell enhancer mm9_chr13:93756683-93756983 Neighboring gene predicted gene, 41019

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Adolph KW. Gene, 2004 Apr 14. PMID 15087125
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
metaxin-3
Names
pleckstrin homology domain containing, family M (with RUN domain) member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162945.2 → NP_001156417.1  metaxin-3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    CT025667
    Consensus CDS
    CCDS49328.1
    UniProtKB/TrEMBL
    D3YTP3
    Related
    ENSMUSP00000075526.4, ENSMUST00000076169.4
    Conserved Domains (2) summary
    cd03212
    Location:105 → 241
    GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
    cd03078
    Location:5 → 77
    GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...

RNA

  1. NR_160868.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT025667

  2. NR_160869.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT025667

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92981251..92994738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517710.2 → XP_006517773.1  metaxin-3 isoform X1

    Conserved Domains (2) summary
    cd03212
    Location:105 → 241
    GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
    pfam10568
    Location:23 → 142
    Tom37; Outer mitochondrial membrane transport complex protein

  2. XM_006517716.3 → XP_006517779.1  metaxin-3 isoform X2

    See identical proteins and their annotated locations for XP_006517779.1

    Conserved Domains (3) summary
    pfam10568
    Location:23 → 142
    Tom37; Outer mitochondrial membrane transport complex protein
    pfam14650
    Location:14 → 25
    FAM75; FAM75 family
    cl02776
    Location:105 → 196
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  3. XM_006517715.2 → XP_006517778.1  metaxin-3 isoform X2

    See identical proteins and their annotated locations for XP_006517778.1

    Conserved Domains (3) summary
    pfam10568
    Location:23 → 142
    Tom37; Outer mitochondrial membrane transport complex protein
    pfam14650
    Location:14 → 25
    FAM75; FAM75 family
    cl02776
    Location:105 → 196
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RNA

  1. XR_004938036.1 RNA Sequence

  2. XR_004938038.1 RNA Sequence

  3. XR_004938037.1 RNA Sequence

  4. XR_004938039.1 RNA Sequence

  5. XR_004938040.1 RNA Sequence

  6. XR_004938041.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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