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Kcnf1 potassium voltage-gated channel, subfamily F, member 1 [ Mus musculus (house mouse) ]

Gene ID: 382571, updated on 21-Apr-2024

Summary

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Official Symbol
Kcnf1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily F, member 1provided by MGI
Primary source
MGI:MGI:2687399
See related
Ensembl:ENSMUSG00000051726 AllianceGenome:MGI:2687399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv5.1; Gm1182
Summary
Predicted to enable voltage-gated potassium channel activity. Involved in non-motile cilium assembly. Located in ciliary base. Is expressed in heart. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 8.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17222101..17226551, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17172100..17176888, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31651 Neighboring gene STARR-positive B cell enhancer ABC_E7121 Neighboring gene RIKEN cDNA 2410004P03 gene Neighboring gene solute carrier family 66 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E11504 Neighboring gene STARR-seq mESC enhancer starr_31652 Neighboring gene STARR-seq mESC enhancer starr_31653 Neighboring gene STARR-seq mESC enhancer starr_31654 Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. Slaats GG, et al. J Cell Sci, 2015 Dec 15. PMID 26546361, Free PMC Article
  2. Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption. Johnson HL, et al. BMC Genomics, 2013 Oct 3. PMID 24090483, Free PMC Article
  3. Ion channel expression in the developing enteric nervous system. Hirst CS, et al. PLoS One, 2015. PMID 25798587, Free PMC Article
  4. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
  5. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC62472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily F member 1
Names
voltage-gated potassium channel subunit Kv5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201531.5 → NP_963289.3  potassium voltage-gated channel subfamily F member 1

    Status: VALIDATED

    Source sequence(s)
    AC159312
    Consensus CDS
    CCDS25825.2
    UniProtKB/Swiss-Prot
    Q7TSH7
    Related
    ENSMUSP00000131480.3, ENSMUST00000170580.3
    Conserved Domains (2) summary
    cd18381
    Location:23 → 138
    BTB_POZ_Kv5_KCNF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels
    pfam00520
    Location:181 → 417
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17222101..17226551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSH7.1 GenPept UniProtKB/Swiss-Prot:Q7TSH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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