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Ankfn1 ankyrin-repeat and fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 382543, updated on 21-Apr-2024

Summary

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Official Symbol
Ankfn1provided by MGI
Official Full Name
ankyrin-repeat and fibronectin type III domain containing 1provided by MGI
Primary source
MGI:MGI:2686021
See related
Ensembl:ENSMUSG00000047773 AllianceGenome:MGI:2686021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nmf9; mWAKE; Gm1175; 4932411E22Rik
Summary
Acts upstream of or within behavioral fear response; equilibrioception; and locomotor rhythm. Predicted to be active in spindle. Orthologous to human ANKFN1 (ankyrin repeat and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 7.9), CNS E18 (RPKM 1.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 54.34 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (89280918..89668727, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (89390092..89777901, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene noggin Neighboring gene predicted gene, 42088 Neighboring gene STARR-seq mESC enhancer starr_30401 Neighboring gene STARR-seq mESC enhancer starr_30402 Neighboring gene STARR-seq mESC enhancer starr_30405 Neighboring gene STARR-seq mESC enhancer starr_30406 Neighboring gene predicted gene, 34619 Neighboring gene predicted gene, 34677 Neighboring gene STARR-positive B cell enhancer ABC_E2364 Neighboring gene phosphatidylcholine transfer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of mWake expression in the murine brain. Bell BJ, et al. J Comp Neurol, 2021 Jun. PMID 33140455, Free PMC Article
  2. Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Concepcion D, et al. Genetics, 2004 Oct. PMID 15514066, Free PMC Article
  3. Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. Zhang S, et al. PLoS Genet, 2015 Jul. PMID 26131556, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5)  1 citation

General gene information

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Homology

Clone Names

  • MGC175922

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within equilibrioception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of bipolar cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin-repeat and fibronectin type III domain-containing 1
Names
ankyrin repeat and fibronectin type-III domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327810.1 → NP_001314739.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645903, AL662930, AL672175, AL672280, AL772375
    UniProtKB/TrEMBL
    A0A140LIW7
    Related
    ENSMUSP00000158789.2, ENSMUST00000238273.3

  2. NM_172534.2 → NP_766122.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform 2

    See identical proteins and their annotated locations for NP_766122.1

    Status: VALIDATED

    Source sequence(s)
    AK029964
    Consensus CDS
    CCDS25237.1
    UniProtKB/TrEMBL
    B2KGG3, Q8CDJ6
    Related
    ENSMUSP00000049776.2, ENSMUST00000050983.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    89280918..89668727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246107.1 → XP_030101967.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LIW7
    Conserved Domains (3) summary
    cd00063
    Location:222 → 293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00045
    Location:66 → 100
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:70 → 123
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_017314636.3 → XP_017170125.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LIW7
    Related
    ENSMUSP00000146987.2, ENSMUST00000207815.2
    Conserved Domains (3) summary
    cd00063
    Location:222 → 293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00045
    Location:66 → 100
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:70 → 123
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_030246105.2 → XP_030101965.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LIW7
    Conserved Domains (3) summary
    cd00063
    Location:222 → 293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00045
    Location:66 → 100
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:70 → 123
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_030246106.2 → XP_030101966.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LIW7
    Conserved Domains (3) summary
    cd00063
    Location:222 → 293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00045
    Location:66 → 100
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:70 → 123
    Ank_2; Ankyrin repeats (3 copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080933.1: Suppressed sequence

    Description
    NM_001080933.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A571BF63.1 GenPept UniProtKB/Swiss-Prot:A0A571BF63

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