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Poc1b POC1 centriolar protein B [ Mus musculus (house mouse) ]

Gene ID: 382406, updated on 30-Apr-2024

Summary

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Official Symbol
Poc1bprovided by MGI
Official Full Name
POC1 centriolar protein Bprovided by MGI
Primary source
MGI:MGI:1918511
See related
Ensembl:ENSMUSG00000019952 AllianceGenome:MGI:1918511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr51b; 4933430F16Rik
Summary
Predicted to be involved in cell population proliferation; organelle assembly; and retina homeostasis. Predicted to act upstream of or within cell projection organization. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole and ciliary basal body. Is expressed in ductus deferens; epididymis; ileum; metanephros; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 19.9), CNS E11.5 (RPKM 7.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C3- D1; 10 51.06 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98942918..99033936)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99107082..99198074)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:98376846-98377147 Neighboring gene predicted gene, 53607 Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene STARR-positive B cell enhancer ABC_E3912 Neighboring gene STARR-seq mESC enhancer starr_27702 Neighboring gene STARR-seq mESC enhancer starr_27703 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98589429-98589538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98590442-98590625 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98594927-98595144 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene STARR-seq mESC enhancer starr_27706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98634758-98634867 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98644928-98645081 Neighboring gene STARR-positive B cell enhancer ABC_E6916 Neighboring gene predicted gene 16239 Neighboring gene STARR-positive B cell enhancer mm9_chr10:98667182-98667482 Neighboring gene STARR-seq mESC enhancer starr_27708 Neighboring gene predicted gene, 34574 Neighboring gene predicted gene, 34777

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice. Hua J, et al. Hum Mol Genet, 2023 Jul 4. PMID 37070736
  2. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
  3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
    Title: Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POC1 centriolar protein homolog B
Names
WD repeat domain 51B
WD repeat-containing protein 51B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027740.7 → NP_082016.1  POC1 centriolar protein homolog B

    See identical proteins and their annotated locations for NP_082016.1

    Status: VALIDATED

    Source sequence(s)
    AK050233, BC050888, BC144819, CO041491
    Consensus CDS
    CCDS36045.1
    UniProtKB/Swiss-Prot
    Q8BHD1
    UniProtKB/TrEMBL
    A6H699
    Related
    ENSMUSP00000020113.9, ENSMUST00000020113.15
    Conserved Domains (3) summary
    COG2319
    Location:14 → 300
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:10 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:63 → 100
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_153333.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC050888, BC144819, CO041491

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    98942918..99033936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155881.1 → XP_036011774.1  POC1 centriolar protein homolog B isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:4 → 84
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHD1.1 GenPept UniProtKB/Swiss-Prot:Q8BHD1

Gene LinkOut

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