U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bclaf3 Bclaf1 and Thrap3 family member 3 [ Mus musculus (house mouse) ]

Gene ID: 382252, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Bclaf3provided by MGI
Official Full Name
Bclaf1 and Thrap3 family member 3provided by MGI
Primary source
MGI:MGI:2685992
See related
Ensembl:ENSMUSG00000044150 AllianceGenome:MGI:2685992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1146; 2310067E24Rik; A830080D01Rik
Summary
Predicted to enable DNA binding activity and transcription coregulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be part of mediator complex. Is expressed in central nervous system and retina. Orthologous to human BCLAF3 (BCLAF1 and THRAP3 family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 7.7), CNS E14 (RPKM 4.3) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X F4; X 73.55 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (158315639..158376077)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (159532642..159593081)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_48172 Neighboring gene STARR-seq mESC enhancer starr_48173 Neighboring gene STARR-seq mESC enhancer starr_48174 Neighboring gene STARR-positive B cell enhancer mm9_chrX:155970286-155970586 Neighboring gene predicted gene, 39546 Neighboring gene hepatitis B virus x interacting protein pseudogene Neighboring gene predicted gene 15186 Neighboring gene STARR-positive B cell enhancer mm9_chrX:156088144-156088445 Neighboring gene SH3-domain kinase binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:156134996-156135149 Neighboring gene STARR-seq mESC enhancer starr_48175 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene cofilin 1, non-muscle pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1. Chakraborty D, et al. Cell Rep, 2017 Dec 12. PMID 29241531
  2. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. Murakami K, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479180, Free PMC Article
  3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
    Title: A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
  2. lncRNA Panct1 maintains mouse embryonic stem cell identity by regulating TOBF1 recruitment to Oct-Sox sequences in early G1.
    Title: lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
BCLAF1 and THRAP3 family member 3
Names
uncharacterized protein CXorf23 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033472.2 → NP_001028644.2  BCLAF1 and THRAP3 family member 3 isoform 1

    See identical proteins and their annotated locations for NP_001028644.2

    Status: VALIDATED

    Source sequence(s)
    AL672284, BC075674
    Consensus CDS
    CCDS30503.2
    UniProtKB/Swiss-Prot
    A2AG56, A2AG57, A2AG58, Q3UM32, Q8BRL2
    Related
    ENSMUSP00000108083.2, ENSMUST00000112464.8
    Conserved Domains (1) summary
    pfam15440
    Location:12 → 631
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  2. NM_001358939.1 → NP_001345868.1  BCLAF1 and THRAP3 family member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672284
    Conserved Domains (1) summary
    pfam15440
    Location:3 → 665
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  3. NM_001358940.1 → NP_001345869.1  BCLAF1 and THRAP3 family member 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672284
    Conserved Domains (1) summary
    pfam15440
    Location:3 → 666
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  4. NM_001358941.1 → NP_001345870.1  BCLAF1 and THRAP3 family member 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672284
    Conserved Domains (1) summary
    pfam15440
    Location:3 → 665
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  5. NM_001358942.1 → NP_001345871.1  BCLAF1 and THRAP3 family member 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672284
    Consensus CDS
    CCDS90769.1
    Related
    ENSMUSP00000051031.7, ENSMUST00000057180.13
    Conserved Domains (1) summary
    pfam15440
    Location:3 → 590
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. NR_152562.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672284

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    158315639..158376077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247837.3 → XP_011246139.1  BCLAF1 and THRAP3 family member 3 isoform X1

    Conserved Domains (1) summary
    pfam15440
    Location:3 → 637
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  2. XM_017318534.3 → XP_017174023.1  BCLAF1 and THRAP3 family member 3 isoform X2

    UniProtKB/Swiss-Prot
    A2AG58
    Conserved Domains (1) summary
    pfam15440
    Location:3 → 590
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. XR_004940348.1 RNA Sequence

  2. XR_004940350.1 RNA Sequence

  3. XR_004940351.1 RNA Sequence

  4. XR_004940349.1 RNA Sequence

  5. XR_003953013.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AG58.1 GenPept UniProtKB/Swiss-Prot:A2AG58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous