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Cep162 centrosomal protein 162 [ Mus musculus (house mouse) ]

Gene ID: 382090, updated on 21-Apr-2024

Summary

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Official Symbol
Cep162provided by MGI
Official Full Name
centrosomal protein 162provided by MGI
Primary source
MGI:MGI:1925343
See related
Ensembl:ENSMUSG00000056919 AllianceGenome:MGI:1925343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1009; 4922501C03Rik
Summary
Predicted to be involved in cilium assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in cytoplasm; microtubule; and nucleus. Predicted to be active in axonemal microtubule; centriole; and centrosome. Orthologous to human CEP162 (centrosomal protein 162). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.6), CNS E14 (RPKM 2.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.1; 9 46.78 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (87071626..87137589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (87189573..87255536, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8282 Neighboring gene melanocortin 2 receptor accessory protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:87150069-87150178 Neighboring gene STARR-seq mESC enhancer starr_24844 Neighboring gene predicted gene, 51416 Neighboring gene predicted gene 9540 Neighboring gene STARR-seq mESC enhancer starr_24845 Neighboring gene T-box18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. Leon A, et al. Oncogene, 2006 Mar 23. PMID 16302001
  2. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
  3. Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. Tomsig JL, et al. J Biol Chem, 2003 Mar 21. PMID 12522145
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1009

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axonemal microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 162 kDa
Names
protein QN1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199316.2 → NP_955020.2  centrosomal protein of 162 kDa

    See identical proteins and their annotated locations for NP_955020.2

    Status: VALIDATED

    Source sequence(s)
    AI049385, AK129260, AK135482, BB413728, BC028799, BF465741, BF721651, CB246096, CK639077, CN456181
    Consensus CDS
    CCDS52879.1
    UniProtKB/Swiss-Prot
    B9EKN3, Q6P262, Q6ZQ06
    UniProtKB/TrEMBL
    B9EKT8
    Related
    ENSMUSP00000091319.5, ENSMUST00000093802.6
    Conserved Domains (1) summary
    COG1196
    Location:617 → 1301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    87071626..87137589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244438.1 → XP_030100298.1  centrosomal protein of 162 kDa isoform X1

    UniProtKB/TrEMBL
    B9EKT8
    Conserved Domains (1) summary
    TIGR02168
    Location:422 → 1165
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006511263.4 → XP_006511326.1  centrosomal protein of 162 kDa isoform X2

    Conserved Domains (1) summary
    TIGR02168
    Location:31 → 774
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006511264.1 → XP_006511327.1  centrosomal protein of 162 kDa isoform X3

    Conserved Domains (1) summary
    pfam06785
    Location:610 → 731
    UPF0242; Uncharacterized protein family (UPF0242)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ06.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ06

Gene LinkOut

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