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Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 382051, updated on 11-Apr-2024

Summary

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Official Symbol
Pdp2provided by MGI
Official Full Name
pyruvate dehydrogenase phosphatase catalytic subunit 2provided by MGI
Primary source
MGI:MGI:1918878
See related
Ensembl:ENSMUSG00000048371 AllianceGenome:MGI:1918878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1705; mKIAA1348; 4833426J09Rik
Summary
Predicted to enable [pyruvate dehydrogenase (lipoamide)] phosphatase activity and protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrion. Is expressed in cerebral cortex. Orthologous to human PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 11.2), heart adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pdp2 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105318104..105325658)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104591472..104599026)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene carbonic anhydrase 7 Neighboring gene STARR-positive B cell enhancer ABC_E2873 Neighboring gene STARR-seq mESC enhancer starr_22513 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1767 Neighboring gene STARR-seq mESC enhancer starr_22514 Neighboring gene STARR-positive B cell enhancer mm9_chr8:107126666-107126966 Neighboring gene VISTA enhancer mm1666 Neighboring gene cadherin 16 Neighboring gene Ras-related associated with diabetes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. Kono M, et al. Proc Natl Acad Sci U S A, 2018 Sep 11. PMID 30150402, Free PMC Article
  2. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Yu C, et al. Nat Struct Mol Biol, 2016 May. PMID 27065194
  3. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
  4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1348

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial
Names
pyruvate dehydrogenase phosphatase isoenzyme 2
pyruvate dehyrogenase phosphatase catalytic subunit 2
NP_001019777.1
XP_006531223.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024606.2 → NP_001019777.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001019777.1

    Status: VALIDATED

    Source sequence(s)
    AC138617
    Consensus CDS
    CCDS22582.1
    UniProtKB/Swiss-Prot
    Q504M2
    UniProtKB/TrEMBL
    Q5DTY5
    Related
    ENSMUSP00000092821.4, ENSMUST00000059588.8
    Conserved Domains (1) summary
    cd00143
    Location:112 → 520
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105318104..105325658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531160.4 → XP_006531223.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531223.1

    UniProtKB/Swiss-Prot
    Q504M2
    UniProtKB/TrEMBL
    Q5DTY5
    Conserved Domains (1) summary
    cd00143
    Location:112 → 520
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504M2.1 GenPept UniProtKB/Swiss-Prot:Q504M2

Gene LinkOut

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