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Cnep1r1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 382030, updated on 5-Mar-2024

Summary

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Official Symbol
Cnep1r1provided by MGI
Official Full Name
CTD nuclear envelope phosphatase 1 regulatory subunit 1provided by MGI
Primary source
MGI:MGI:1921981
See related
Ensembl:ENSMUSG00000036810 AllianceGenome:MGI:1921981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEP1-R1; Tmem188; 5033428A16Rik
Summary
Predicted to be involved in positive regulation of protein dephosphorylation; positive regulation of triglyceride biosynthetic process; and protein localization to nucleus. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Predicted to be active in cytoplasm. Orthologous to human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 12.6), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cnep1r1 in Genome Data Viewer
Location:
8 C3; 8 43.06 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88845344..88861825)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88118716..88135197)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39217 Neighboring gene STARR-seq mESC enhancer starr_22225 Neighboring gene predicted gene 2716 Neighboring gene STARR-seq mESC enhancer starr_22226 Neighboring gene RAB11a, member RAS oncogene family pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1765 Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene terminal nucleotidyltransferase 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Xia P, et al. Nat Immunol, 2018 Feb. PMID 29292386
  2. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. Han S, et al. J Biol Chem, 2012 Jan 27. PMID 22134922, Free PMC Article
  3. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
    Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC171143

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Nem1-Spo7 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear envelope phosphatase-regulatory subunit 1
Names
transmembrane protein 188

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029074.3 → NP_083350.2  nuclear envelope phosphatase-regulatory subunit 1

    See identical proteins and their annotated locations for NP_083350.2

    Status: VALIDATED

    Source sequence(s)
    AC126034, AK146578, BY124150
    Consensus CDS
    CCDS52628.1
    UniProtKB/Swiss-Prot
    A7E1Z4, Q3UJ81, Q8VEG8, Q9D3Q4
    UniProtKB/TrEMBL
    D3Z6J3
    Related
    ENSMUSP00000092839.4, ENSMUST00000095214.10
    Conserved Domains (1) summary
    pfam09771
    Location:5 → 122
    Tmemb_18A; Transmembrane protein 188

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    88845344..88861825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248420.2 → XP_011246722.1  nuclear envelope phosphatase-regulatory subunit 1 isoform X1

    UniProtKB/TrEMBL
    D3Z6J3
    Conserved Domains (1) summary
    pfam09771
    Location:5 → 112
    Tmemb_18A; Transmembrane protein 188

  2. XM_011248421.2 → XP_011246723.1  nuclear envelope phosphatase-regulatory subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_011246723.1

    UniProtKB/TrEMBL
    D3Z6J3
    Related
    ENSMUSP00000113207.2, ENSMUST00000117775.2
    Conserved Domains (1) summary
    pfam09771
    Location:5 → 112
    Tmemb_18A; Transmembrane protein 188
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJ81.1 GenPept UniProtKB/Swiss-Prot:Q3UJ81

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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