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Lmtk3 lemur tyrosine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 381983, updated on 11-Apr-2024

Summary

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Official Symbol
Lmtk3provided by MGI
Official Full Name
lemur tyrosine kinase 3provided by MGI
Primary source
MGI:MGI:3039582
See related
Ensembl:ENSMUSG00000062044 AllianceGenome:MGI:3039582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
aatyk3
Summary
Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in Golgi apparatus; cell projection; and membrane. Predicted to be integral component of membrane. Is expressed in liver lobe and nervous system. Orthologous to human LMTK3 (lemur tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 35.4), CNS E14 (RPKM 29.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.5 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45432577..45456315)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45783134..45804144)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family, cytosolic, 2B, member 1 Neighboring gene STARR-seq mESC enhancer starr_18855 Neighboring gene predicted gene, 31597 Neighboring gene predicted gene, 39009 Neighboring gene predicted gene 5897 Neighboring gene STARR-positive B cell enhancer ABC_E6546 Neighboring gene STARR-positive B cell enhancer ABC_E8838 Neighboring gene STARR-positive B cell enhancer ABC_E549 Neighboring gene cytohesin 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate-rich WD repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking. Montrose K, et al. Neuroscience, 2019 Aug 21. PMID 31310731
  2. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. Inoue T, et al. J Neurosci, 2014 Apr 23. PMID 24760852, Free PMC Article
  3. Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Tomomura M, et al. Neuroscience, 2007 Aug 24. PMID 17651901
  4. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction. Further investigation revealed abnormalities in GluA1 trafficking after AMPA stimulation in Lmtk3-KO neurons, along with a reduction in GluA1 expression in the post-synaptic density.
    Title: Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking.
  2. the dopamine metabolite levels and dopamine turnover rate are increased in the striata of Lmtk3(-/-) mice compared with controls. In addition, we found that LMTK3 is involved in the endocytic trafficking of N-methyl-d-aspartate receptors.
    Title: LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC90743

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase LMTK3
Names
apoptosis-associated tyrosine kinase 3
NP_001005511.2
NP_001277919.1
XP_006541027.1
XP_017177816.1
XP_030098591.1
XP_030098592.1
XP_030098593.1
XP_030098594.1
XP_030098595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005511.4 → NP_001005511.2  serine/threonine-protein kinase LMTK3 precursor

    See identical proteins and their annotated locations for NP_001005511.2

    Status: VALIDATED

    Source sequence(s)
    AC149053, AC167242
    Consensus CDS
    CCDS39961.1
    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    UniProtKB/TrEMBL
    A0A0R4J0W7
    Related
    ENSMUSP00000072388.6, ENSMUST00000072580.12
    Conserved Domains (1) summary
    cl21453
    Location:135 → 410
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001290990.2 → NP_001277919.1  serine/threonine-protein kinase LMTK3 precursor

    See identical proteins and their annotated locations for NP_001277919.1

    Status: VALIDATED

    Source sequence(s)
    AC149053, AC167242
    Consensus CDS
    CCDS39961.1
    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    UniProtKB/TrEMBL
    A0A0R4J0W7
    Related
    ENSMUSP00000112592.2, ENSMUST00000120005.10
    Conserved Domains (1) summary
    cl21453
    Location:135 → 410
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_110987.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149053, AC167242

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45432577..45456315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322327.3 → XP_017177816.1  serine/threonine-protein kinase LMTK3 isoform X2

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    UniProtKB/TrEMBL
    A0A0R4J0W7
    Conserved Domains (1) summary
    cl21453
    Location:135 → 410
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030242731.2 → XP_030098591.1  serine/threonine-protein kinase LMTK3 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GSR5
    Conserved Domains (1) summary
    cl21453
    Location:162 → 437
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030242732.2 → XP_030098592.1  serine/threonine-protein kinase LMTK3 isoform X3

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    Conserved Domains (1) summary
    cl21453
    Location:24 → 299
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030242734.2 → XP_030098594.1  serine/threonine-protein kinase LMTK3 isoform X4

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    Conserved Domains (1) summary
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030242735.2 → XP_030098595.1  serine/threonine-protein kinase LMTK3 isoform X5

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    Conserved Domains (1) summary
    cl21453
    Location:34 → 179
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006540964.5 → XP_006541027.1  serine/threonine-protein kinase LMTK3 isoform X2

    See identical proteins and their annotated locations for XP_006541027.1

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    UniProtKB/TrEMBL
    A0A0R4J0W7
    Conserved Domains (1) summary
    cl21453
    Location:135 → 410
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030242733.2 → XP_030098593.1  serine/threonine-protein kinase LMTK3 isoform X4

    UniProtKB/Swiss-Prot
    A6BLZ0, Q52KF1, Q5XJV6
    Conserved Domains (1) summary
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004934123.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XJV6.1 GenPept UniProtKB/Swiss-Prot:Q5XJV6

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