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Itgad integrin, alpha D [ Mus musculus (house mouse) ]

Gene ID: 381924, updated on 11-Apr-2024

Summary

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Official Symbol
Itgadprovided by MGI
Official Full Name
integrin, alpha Dprovided by MGI
Primary source
MGI:MGI:3578624
See related
Ensembl:ENSMUSG00000070369 AllianceGenome:MGI:3578624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd11d
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within activated T cell proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Orthologous to human ITGAD (integrin subunit alpha D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 20.4), testis adult (RPKM 5.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 70.0 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127773105..127822988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128173933..128205504)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrin alpha X Neighboring gene mitochondrial carrier triple repeat 1 pseudogene Neighboring gene predicted gene, 39091 Neighboring gene RIKEN cDNA 4931431B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E10479 Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135380811-135380920 Neighboring gene STARR-positive B cell enhancer ABC_E2253 Neighboring gene STARR-positive B cell enhancer ABC_E8212 Neighboring gene zinc finger protein 696 Neighboring gene armadillo repeat containing 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135396171-135396397 Neighboring gene transforming growth factor beta 1 induced transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modification of Extracellular Matrix by the Product of DHA Oxidation Switches Macrophage Adhesion Patterns and Promotes Retention of Macrophages During Chronic Inflammation. Casteel JL, et al. Front Immunol, 2022. PMID 35720381, Free PMC Article
  2. Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. Miyazaki Y, et al. J Immunol, 2008 Jan 1. PMID 18097061, Free PMC Article
  3. Disruption of the beta2-integrin CD11d (alphaDbeta2) gene fails to protect against experimental autoimmune encephalomyelitis. Adams JE, et al. J Neuroimmunol, 2007 Mar. PMID 17254640, Free PMC Article
  4. Frontline Science: The expression of integrin α(D) β(2) (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis. Bailey WP, et al. J Leukoc Biol, 2021 May. PMID 33438263, Free PMC Article
  5. Inhibition of integrin α(D)β(2)-mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation. Cui K, et al. J Biol Chem, 2019 Sep 27. PMID 31395659, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frontline Science: The expression of integrin alphaD beta2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis.
    Title: Frontline Science: The expression of integrin α(D) β(2) (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis.
  2. findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development.
    Title: The Upregulation of Integrin α(D)β(2) (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.
  3. The results indicate that both Mac-1 and alphaDbeta2 support macrophage fusion with Mac-1 playing a dominant role
    Title: The Role of Integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in Macrophage Fusion.
  4. Relative white adipose tissue (WAT) expression of CD11d was massively induced by obesity to an extent greater than any other inflammatory marker (to >300-fold of controls in the 45 and 60% fat groups) and this induction was WAT specific.
    Title: Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.
  5. These studies identify previously unrecognized and unique activities of integrin alphaDbeta2, and macrophages that express it, in host defense and injury.
    Title: Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin alpha-D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029872.3 → NP_001025043.3  integrin alpha-D precursor

    See identical proteins and their annotated locations for NP_001025043.3

    Status: VALIDATED

    Source sequence(s)
    AC124566, AW495405
    Consensus CDS
    CCDS21890.2
    UniProtKB/TrEMBL
    E9PXZ7, Q3U171
    Related
    ENSMUSP00000033051.10, ENSMUST00000033051.16
    Conserved Domains (4) summary
    smart00191
    Location:559 → 614
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156 → 367
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1165 → 1178
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:666 → 1003
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127773105..127822988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153200.1 → XP_036009093.1  integrin alpha-D isoform X1

    UniProtKB/TrEMBL
    Q3U171
    Conserved Domains (3) summary
    smart00191
    Location:559 → 614
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156 → 367
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:666 → 1068
    Integrin_alpha2; Integrin alpha

  2. XM_006507971.3 → XP_006508034.1  integrin alpha-D isoform X2

    UniProtKB/TrEMBL
    Q3U171
    Conserved Domains (4) summary
    smart00191
    Location:549 → 604
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156 → 357
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1155 → 1168
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:656 → 1058
    Integrin_alpha2; Integrin alpha

  3. XM_006507972.3 → XP_006508035.1  integrin alpha-D isoform X3

    UniProtKB/Swiss-Prot
    Q3V0T4
    UniProtKB/TrEMBL
    H3BKX8
    Related
    ENSMUSP00000135572.2, ENSMUST00000177111.8
    Conserved Domains (4) summary
    smart00191
    Location:523 → 578
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:156 → 331
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1129 → 1142
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:630 → 1032
    Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177632.1: Suppressed sequence

    Description
    NM_001177632.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V0T4.1 GenPept UniProtKB/Swiss-Prot:Q3V0T4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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