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Taok2 TAO kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 381921, updated on 21-Apr-2024

Summary

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Official Symbol
Taok2provided by MGI
Official Full Name
TAO kinase 2provided by MGI
Primary source
MGI:MGI:1915919
See related
Ensembl:ENSMUSG00000059981 AllianceGenome:MGI:1915919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSK; PSK1; TAO1; TAO2; MAP3K17; mKIAA0881; B230344N16; 1110033K02Rik
Summary
Enables neuropilin binding activity. Involved in neuron projection morphogenesis; positive regulation of JNK cascade; and regulation of actin cytoskeleton organization. Located in axonal growth cone and dendritic growth cone. Colocalizes with actin cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 32.8), ovary adult (RPKM 27.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.25 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126464848..126485468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126865674..126886296, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E2849 Neighboring gene transmembrane protein 219 Neighboring gene predicted gene, 23445 Neighboring gene STARR-positive B cell enhancer ABC_E10477 Neighboring gene potassium channel tetramerisation domain containing 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model. Scharrenberg R, et al. Mol Psychiatry, 2022 Nov. PMID 36123424, Free PMC Article
  2. Taok2 controls behavioral response to ethanol in mice. Kapfhamer D, et al. Genes Brain Behav, 2013 Feb. PMID 22883308, Free PMC Article
  3. Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. de Anda FC, et al. Nat Neurosci, 2012 Jun 10. PMID 22683681, Free PMC Article
  4. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
  5. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.
    Title: TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.
  2. disruption of the Taok2 gene alters behavioral response to ethanol.
    Title: Taok2 controls behavioral response to ethanol in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0881

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables neuropilin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropilin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in basal dendrite arborization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in basal dendrite arborization ISO
Inferred from Sequence Orthology
more info
  
involved_in basal dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basal dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase TAO2
Names
TAO kinase 2TAO kinase 2
thousand and one amino acid protein 2
NP_001157246.1
NP_001157247.1
XP_030098581.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163774.2 → NP_001157246.1  serine/threonine-protein kinase TAO2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC122863, AC124505
    Consensus CDS
    CCDS52404.1
    UniProtKB/Swiss-Prot
    Q6ZQ29
    Related
    ENSMUSP00000071246.5, ENSMUST00000071268.11
    Conserved Domains (2) summary
    COG0419
    Location:481 → 920
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06634
    Location:12 → 319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

  2. NM_001163775.2 → NP_001157247.1  serine/threonine-protein kinase TAO2 isoform 2

    See identical proteins and their annotated locations for NP_001157247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC122863, AC124505
    Consensus CDS
    CCDS52403.1
    UniProtKB/Swiss-Prot
    Q6ZQ29, Q7TSS8
    Related
    ENSMUSP00000112963.2, ENSMUST00000117394.2
    Conserved Domains (2) summary
    smart00220
    Location:28 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12 → 319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126464848..126485468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242721.2 → XP_030098581.1  serine/threonine-protein kinase TAO2 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:481 → 920
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06634
    Location:12 → 319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RNA

  1. XR_001785578.3 RNA Sequence

  2. XR_003946498.1 RNA Sequence

  3. XR_001785580.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ29.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ29

Gene LinkOut

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