Clec4b2 C-type lectin domain family 4, member b2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4b2provided by MGI
Official Full Name: C-type lectin domain family 4, member b2provided by MGI
Primary source: MGI:MGI:3588267
See related: Ensembl:ENSMUSG00000067767 AllianceGenome:MGI:3588267
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aplra1; mDCAR1; F830043G12Rik
Summary: Predicted to enable carbohydrate binding activity. Acts upstream of or within positive regulation of antigen processing and presentation. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F2; 6 58.25 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (123149827..123181630)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (123172868..123204671)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that mDCAR1 is a functional receptor on cells of the immune system and provides further insights into the regulation of immune responses by C-type lectin receptors.
Title: Enhanced dendritic cell-induced immune responses mediated by the novel C-type lectin receptor mDCAR1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 4, member b2

Names: antigen presenting cell lectin-like receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004159.2 → NP_001004159.1 C-type lectin domain family 4, member b2

See identical proteins and their annotated locations for NP_001004159.1

Status: VALIDATED

Source sequence(s)

AC164111

Consensus CDS

CCDS20511.1

UniProtKB/TrEMBL

Q67DU8

Related

ENSMUSP00000085802.6, ENSMUST00000088455.6

Conserved Domains (1) summary

cd03590
Location:79 → 203

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

123149827..123181630

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321668.1 → XP_017177157.1 C-type lectin domain family 4, member b2 isoform X1

Conserved Domains (1) summary

cl02432
Location:79 → 124

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain