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Tsen2 tRNA splicing endonuclease subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 381802, updated on 11-Apr-2024

Summary

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Official Symbol
Tsen2provided by MGI
Official Full Name
tRNA splicing endonuclease subunit 2provided by MGI
Primary source
MGI:MGI:2141599
See related
Ensembl:ENSMUSG00000042389 AllianceGenome:MGI:2141599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to act upstream of or within mRNA processing and tRNA processing. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115521652..115555297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115544659..115578350)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36301 Neighboring gene predicted gene, 36355 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115510052-115510235 Neighboring gene STARR-seq mESC enhancer starr_17082 Neighboring gene STARR-positive B cell enhancer mm9_chr6:115533495-115533796 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115551710-115551893 Neighboring gene makorin, ring finger protein, 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115570008-115570117 Neighboring gene v-raf-leukemia viral oncogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. Bopp SE, et al. PLoS One, 2010 May 28. PMID 20531941, Free PMC Article
  2. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
  3. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC69703

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-intron endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-intron endonuclease complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA-splicing endonuclease subunit Sen2
Names
tRNA splicing endonuclease 2 homolog
tRNA-intron endonuclease Sen2
NP_001398713.1
NP_001398714.1
NP_001398715.1
NP_950198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411784.1 → NP_001398713.1  tRNA-splicing endonuclease subunit Sen2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153828

  2. NM_001411785.1 → NP_001398714.1  tRNA-splicing endonuclease subunit Sen2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153828

  3. NM_001411786.1 → NP_001398715.1  tRNA-splicing endonuclease subunit Sen2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153828

  4. NM_199033.3 → NP_950198.1  tRNA-splicing endonuclease subunit Sen2 isoform 1

    See identical proteins and their annotated locations for NP_950198.1

    Status: VALIDATED

    Source sequence(s)
    AC153828
    Consensus CDS
    CCDS20440.1
    UniProtKB/Swiss-Prot
    Q3UYG6, Q6P7W5
    Related
    ENSMUSP00000038211.8, ENSMUST00000040234.9
    Conserved Domains (3) summary
    COG1676
    Location:292 → 420
    SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
    pfam01974
    Location:334 → 417
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
    pfam02778
    Location:278 → 324
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115521652..115555297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7W5.1 GenPept UniProtKB/Swiss-Prot:Q6P7W5

Gene LinkOut

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