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Tatdn2 TatD DNase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 381801, updated on 3-Apr-2024

Summary

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Official Symbol
Tatdn2provided by MGI
Official Full Name
TatD DNase domain containing 2provided by MGI
Primary source
MGI:MGI:3576210
See related
Ensembl:ENSMUSG00000056952 AllianceGenome:MGI:3576210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0218
Summary
Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TATDN2 (TatD DNase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.5), spleen adult (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tatdn2 in Genome Data Viewer
Location:
6 E3; 6 52.83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113674090..113688030)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113697050..113711082)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2798 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene interleukin-1 receptor-associated kinase 2 Neighboring gene STARR-seq mESC enhancer starr_17046 Neighboring gene STARR-positive B cell enhancer ABC_E6467 Neighboring gene STARR-positive B cell enhancer ABC_E6468 Neighboring gene STARR-positive B cell enhancer ABC_E3671 Neighboring gene STARR-positive B cell enhancer ABC_E9672 Neighboring gene STARR-positive B cell enhancer ABC_E1707 Neighboring gene STARR-seq mESC enhancer starr_17051 Neighboring gene STARR-positive B cell enhancer ABC_E6469 Neighboring gene microRNA 7042 Neighboring gene ghrelin Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. Hardy MP, et al. J Biol Chem, 2004 Jun 25. PMID 15082713
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0218

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative deoxyribonuclease TATDN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033463.5 → NP_001028635.2  putative deoxyribonuclease TATDN2 isoform 2

    See identical proteins and their annotated locations for NP_001028635.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
    Source sequence(s)
    AC117596, AC153987
    Consensus CDS
    CCDS20431.1
    UniProtKB/TrEMBL
    F8VQE6, Q3U179
    Related
    ENSMUSP00000086412.5, ENSMUST00000089018.11
    Conserved Domains (2) summary
    COG1099
    Location:456 → 722
    COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
    pfam01026
    Location:457 → 721
    TatD_DNase; TatD related DNase

  2. NM_001347356.2 → NP_001334285.1  putative deoxyribonuclease TATDN2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC117596, AC153987
    Consensus CDS
    CCDS85124.1
    UniProtKB/TrEMBL
    B7ZNL9, Q571H2
    Related
    ENSMUSP00000145308.2, ENSMUST00000204753.3

  3. NM_001411779.1 → NP_001398708.1  putative deoxyribonuclease TATDN2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153987

  4. NM_001411780.1 → NP_001398709.1  putative deoxyribonuclease TATDN2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153987

RNA

  1. NR_177929.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153987

  2. NR_177930.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153987

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113674090..113688030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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