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Wee2 WEE1 homolog 2 (S. pombe) [ Mus musculus (house mouse) ]

Gene ID: 381759, updated on 11-Apr-2024

Summary

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Official Symbol
Wee2provided by MGI
Official Full Name
WEE1 homolog 2 (S. pombe)provided by MGI
Primary source
MGI:MGI:3027899
See related
Ensembl:ENSMUSG00000037159 AllianceGenome:MGI:3027899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wee1B; Gm1065
Summary
Predicted to enable protein tyrosine kinase activity. Involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of phosphorylation. Located in cytoplasm and nucleus. Is expressed in 1-cell stage embryo; olfactory epithelium; and ovary. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 18.82 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40412180..40443749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40435246..40466815)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15673 Neighboring gene transmembrane protein 178B Neighboring gene STARR-seq mESC enhancer starr_15674 Neighboring gene STARR-seq mESC enhancer starr_15675 Neighboring gene STARR-seq mESC enhancer starr_15676 Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_15685 Neighboring gene taste receptor, type 2, member 137 Neighboring gene single-stranded DNA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Liu C, et al. Mol Med Rep, 2013 Jun. PMID 23616086
  2. Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Han SJ, et al. Curr Biol, 2005 Sep 20. PMID 16169490
  3. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Nakanishi M, et al. Genes Cells, 2000 Oct. PMID 11029659
  4. Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. Sang Q, et al. Am J Hum Genet, 2018 Apr 5. PMID 29606300, Free PMC Article
  5. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Oh JS, et al. Science, 2011 Apr 22. PMID 21454751, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos.
    Title: Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos.
  2. findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B
    Title: Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.
  3. Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest.
    Title: Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC60753

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female pronucleus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
wee1-like protein kinase 2
Names
mWee1B
wee1-like protein kinase 1B
wee1B kinase
NP_958758.2
XP_006506389.1
XP_006506390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201370.2 → NP_958758.2  wee1-like protein kinase 2

    See identical proteins and their annotated locations for NP_958758.2

    Status: VALIDATED

    Source sequence(s)
    AK139573, BY725757, CJ200934
    Consensus CDS
    CCDS20029.1
    UniProtKB/Swiss-Prot
    Q4U4S4, Q66JT0, Q7TPV9
    Related
    ENSMUSP00000038754.9, ENSMUST00000038907.9
    Conserved Domains (1) summary
    cl21453
    Location:207 → 477
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40412180..40443749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506326.4 → XP_006506389.1  wee1-like protein kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006506389.1

    UniProtKB/Swiss-Prot
    Q4U4S4, Q66JT0, Q7TPV9
    Conserved Domains (1) summary
    cl21453
    Location:207 → 477
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006506327.4 → XP_006506390.1  wee1-like protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:101 → 371
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JT0.2 GenPept UniProtKB/Swiss-Prot:Q66JT0

Gene LinkOut

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