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N4bp2l2 NEDD4 binding protein 2-like 2 [ Mus musculus (house mouse) ]

Gene ID: 381695, updated on 8-Feb-2024

Summary

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Official Symbol
N4bp2l2provided by MGI
Official Full Name
NEDD4 binding protein 2-like 2provided by MGI
Primary source
MGI:MGI:2687207
See related
Ensembl:ENSMUSG00000029655 AllianceGenome:MGI:2687207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
zag1; Gm38758; 2700092H06Rik
Summary
Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within blastocyst development. Located in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.7), CNS E18 (RPKM 3.4) and 25 other tissues See more
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Genomic context

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Location:
5; 5 G3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150515310..150589213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150599931..150665748, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene breast cancer 2, early onset Neighboring gene predicted gene, 23641 Neighboring gene predicted gene 42529 Neighboring gene NEDD4 binding protein 2-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3639 Neighboring gene STARR-positive B cell enhancer mm9_chr5:151397981-151398282 Neighboring gene STARR-seq mESC enhancer starr_14956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:151414417-151414570 Neighboring gene STARR-positive B cell enhancer ABC_E10368 Neighboring gene STARR-positive B cell enhancer ABC_E2774 Neighboring gene STARR-positive B cell enhancer ABC_E6410 Neighboring gene STARR-positive B cell enhancer ABC_E6411 Neighboring gene STARR-positive B cell enhancer ABC_E3640 Neighboring gene predicted gene, 40353 Neighboring gene STARR-seq mESC enhancer starr_14958 Neighboring gene PDS5 cohesin associated factor B Neighboring gene STARR-positive B cell enhancer ABC_E4810 Neighboring gene predicted gene, 24630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zag expression during aging suppresses proliferation after kidney injury. Schmitt R, et al. J Am Soc Nephrol, 2008 Dec. PMID 18815245, Free PMC Article
  2. Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. Matsuoka T, et al. J Reprod Dev, 2008 Jun. PMID 18360097
  3. Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase. Salipante SJ, et al. Mol Cell Biol, 2009 Aug. PMID 19506020, Free PMC Article
  4. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Won M, et al. Cell Death Differ, 2022 Jun. PMID 34839354, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. increased Zag expression in the aged kidney acts to suppress the proliferative response to injury
    Title: Zag expression during aging suppresses proliferation after kidney injury.
  2. results suggest that ZAG1 may be closely associated with zygotic gene expression in mouse preimplantation embryos
    Title: Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NEDD4-binding protein 2-like 2
Names
phosphonoformate immuno-associated protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362416.1 → NP_001349345.1  NEDD4-binding protein 2-like 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158558, AK038740, BC062895
    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  2. NM_201369.3 → NP_958757.2  NEDD4-binding protein 2-like 2 isoform 2

    See identical proteins and their annotated locations for NP_958757.2

    Status: VALIDATED

    Source sequence(s)
    AC158558, AK038740, AW488478, CA556104, CB231597, CD561511, CF724618, CJ162163
    Consensus CDS
    CCDS19888.2
    UniProtKB/Swiss-Prot
    Q8JZS6
    Related
    ENSMUSP00000113895.2, ENSMUST00000118316.8
    Conserved Domains (2) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain
    cl17190
    Location:396 → 526
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    150515310..150589213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254630.2 → XP_030110490.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  2. XM_030254629.2 → XP_030110489.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  3. XM_036165248.1 → XP_036021141.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  4. XM_036165249.1 → XP_036021142.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  5. XM_036165251.1 → XP_036021144.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:396 → 529
    AAA_33; AAA domain

  6. XM_036165252.1 → XP_036021145.1  NEDD4-binding protein 2-like 2 isoform X2

    Conserved Domains (1) summary
    pfam13671
    Location:17 → 93
    AAA_33; AAA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZS6.2 GenPept UniProtKB/Swiss-Prot:Q8JZS6

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